KCNJ14

KCNJ14
Identifiers
Aliases	KCNJ14, IRK4, KIR2.4, potassium voltage-gated channel subfamily J member 14, potassium inwardly rectifying channel subfamily J member 14
External IDs	OMIM: 603953; MGI: 2384820; HomoloGene: 27086; GeneCards: KCNJ14; OMA:KCNJ14 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,455,574 bp[1] End 48,466,980 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,465,884 bp[2] End 45,474,206 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen stromal cell of endometrium gastrocnemius muscle skin of leg primary visual cortex ventricular zone skin of abdomen muscle of thigh caudate nucleus skeletal muscle tissue Top expressed in layer of retina neural layer of retina anterior horn of spinal cord eyelid olfactory cortex spinal ganglia lower eyelid amygdala upper eyelid trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity inward rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex neuronal cell body plasma membrane dendrite membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3770 211480 Ensembl ENSG00000182324 ENSMUSG00000058743 UniProt Q9UNX9 Q8JZN3 RefSeq (mRNA) NM_170720 NM_013348 NM_145963 RefSeq (protein) NP_037480 NP_666075 Location (UCSC) Chr 19: 48.46 – 48.47 Mb Chr 7: 45.47 – 45.47 Mb PubMed search [3] [4]
Wikidata
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Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as K_ir2.4, is a human gene.^[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.^[5]

• Inward-rectifier potassium ion channel

• KCNJ14+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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