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ABCF2

From Wikipedia, the free encyclopedia
ABCF2
Identifiers
AliasesABCF2, ABC28, EST133090, HUSSY18, HUSSY-18, ATP binding cassette subfamily F member 2
External IDsOMIM: 612510; MGI: 1351657; HomoloGene: 21408; GeneCards: ABCF2; OMA:ABCF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007189

NM_001190443
NM_013853
NM_001359205

RefSeq (protein)

NP_005683
NP_009120

NP_001177372
NP_038881
NP_001346134

Location (UCSC)Chr 7: 151.21 – 151.23 MbChr 5: 24.77 – 24.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.[5][6]

Function

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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.[6]

ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000033050Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028953Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ a b "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2".
  7. ^ Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012). "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells". Journal of Cellular Physiology. 227 (10): 3498–510. doi:10.1002/jcp.24050. PMID 22252987. S2CID 22139132.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.