The religious nature of the program attracted a wide variety of actors and directors such as Jeff Hunter, Ed Asner, Jack Albertson, Beau Bridges, Carol Burnett, Ron Howard, Cindy Williams, Patty Duke, Ann Jillian, Wesley Eure, Bob Hastings, Cicely Tyson, Ricky Kelman, Jack Klugman, Robert Lansing, Randolph Mantooth, Walter Matthau, Deborah Winters, Bob Newhart, Bill Bixby, John Ritter, Michael Shea, Martin Sheen, Marc Daniels, Arthur Hiller, Norman Lloyd, Delbert Mann, Ted Post, Jay Sandrich, and Jack Shea, as well as writers Rod Serling, John T. Dugan, Lan O'Kun, and Michael Crichton.
Was nominated for the Emmy for Outstanding Achievement in Religious Programming in 1972 and 1973 (Primetime Emmy Awards), and won the category each year from 1981 to 1984 (Daytime Emmy Awards).
Paulist Productions, the company behind Insight, kept all of the master tapes of the show in the basement of their offices at 17575 Pacific Coast Highway in Pacific Palisades. This was the oceanfront property where, in 1935, screen star Thelma Todd was found in the garage, slumped over the steering wheel of her convertible, dead at age thirty from carbon monoxide poisoning that was ruled accidental but which many suspected was a homicide, with even her lover, the owner of the property, producer Roland West, being suspected. Built in the 1920s, the 15,000 square-foot landmark, a Spanish-Moorish three-level structure near the Santa Monica Pier, was later sold to Paulist Productions after West died in 1952. It was sold to them at a fraction of market cost by West's widow, singer and actress Lola Lane, who, after West's death, had converted to Catholism and admired Insight's creator and producer, Paulist priest Father Ellwood Kieser. The basement area where the tapes were stored was once a speakeasy club and alleged mobster hangout. UCLA has undergone preservation efforts to restore the approximately 450 reels of tape found there. The irony of the site of Todd's scandalous death as the office for a religious production company was not lost on Father Kieser, who told a reporter that the Paulists "exorcised the place before we moved in," and that his screening room was once the "nightclub's men's bathroom."
Although claiming to be Catholic (or Christian for that matter) many shows in the series had mild swearing.
"The Man Who Mugged God" aired on TBN in 2003 and again in 2004. It marked the first time any show with swearing (albeit very mild) aired on the network.