LTA

LTA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TNR, 4MXV, 4MXW
Dynodwyr
Cyfenwau	LTA, LT, TNFB, TNFSF1, Lymphotoxin alpha, TNLG1E
Dynodwyr allanol	OMIM: 153440 HomoloGene: 497 GeneCards: LTA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • tumor necrosis factor receptor binding • signaling receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • bilen • Cellbilen • extracellular region • extracellular space Prosesau biolegol • positive regulation of chronic inflammatory response to antigenic stimulus • response to hypoxia • response to nutrient • cell-cell signaling • positive regulation of humoral immune response mediated by circulating immunoglobulin • positive regulation of interferon-gamma production • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • humoral immune response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of apoptotic process • lymph node development • positive regulation of glial cell proliferation • negative regulation of fibroblast proliferation • GO:0072468 signal transduction • GO:0051637 defense response to Gram-positive bacterium • GO:0097285 apoptotic process • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4049	n/a
Ensembl	ENSG00000231408 ENSG00000223919 ENSG00000173503 ENSG00000226275 ENSG00000230279 ENSG00000238130 ENSG00000226979	n/a
UniProt	P01374	n/a
RefSeq (mRNA)	NM_000595 NM_001159740	n/a
RefSeq (protein)	NP_000586 NP_001153212	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LTA yw LTA a elwir hefyd yn Lymphotoxin alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LTA.

• "The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study. ". Medicine (Baltimore). 2017. PMID 28489756.
• "Association between Lymphotoxin Alpha (-252G/A and -804C/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis. ". Acta Neurol Taiwan. 2016. PMID 27411794.
• "Polymorphism in the lymphotoxin-alpha gene, position +252 (rs909253), is not associated with preeclampsia development in Brazilian women.". Rev Bras Ginecol Obstet,. 2015. PMID 26561241.
• "LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study.". BMC Cancer. 2015. PMID 26108796.
• "Association of lymphotoxin alpha polymorphism with systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis.". Int J Rheum Dis. 2015. PMID 25931031.