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User:Middleground1/sandbox
SANDBOX Eimear E. Kenny
Introductory Summary
{{Infobox scientist
| name = Eimear E. Kenny
| citizenship = Please Clarify if American or Irish
| nationality = Irish
| workplaces = [[Icahn School of Medicine at Mount Sinai]]</br>[[New York Genome Center]]</br>[[Massachusetts Institute of Technology]]</br>[[California Institute of Technology]]
| alma_mater = [[Trinity College Dublin]]</br>[[University of Leeds]]</br>[[Rockefeller University]]
| known_for = Global genetic diversity research
| website = [https://labs.icahn.mssm.edu/eimearkennylab/people/ Kenny Laboratory]
}}
Eimear Kenny, PhD, is a statistical and population geneticist and Founding Director of the Institute for Genomic Health at the [[Icahn School of Medicine at Mount Sinai]]. She is known for novel approaches to genomics that take into account the diversity of the human population, thereby laying the groundwork for targeted clinical care treatments. Her work utilizes the link between [[genetics]], ancestry and disease, using genomic technologies and [[Outline of machine learning|machine learning methods]] (AI) to explore the connection between genetics, ancestry and disease.<ref name=":0">{{Cite web |title=Eimear Kenny |url=https://www.agbt.org/speaker/eimear-kenny-2/ |access-date=2024-06-09 |website=AGBT |language=en-US}}</ref> This work has advanced the application of population science and medical genomics thereby underscoring the importance of diversity in genomic research and improving the accessibility of clinical care to global populations.<ref>{{Cite web |title=Who We Are |url=https://www.popgenhealth.com/test |access-date=2024-06-09 |website=Population Genomic Health |language=en-US}}</ref><ref>{{Cite news |date=2023-05-10 |title=Updated DNA map better reflects human diversity |url=https://www.bbc.com/news/science-environment-65539594 |access-date=2024-06-10 |language=en-GB}}</ref>
=Research =
Kenny leads a team of experts{{Peacock inline|date=June 2024}} in genetics, computer science, and medicine, focusing on genetic ancestry, large-scale genomics, and medicine.<ref>{{Cite web |title=Mount Sinai Hospital – EMERGE |url=https://emerge.study/mount-sinai/ |access-date=2024-06-10 |language=en-US}}</ref> The lab works to realize genomics' potential to extrapolate human history and evolution in order to inform better clinical medicine models and reduce care inequities.<ref>{{Cite web |title=Eimear E. Kenny, Assistant Professor - eMedEvents |url=https://www.emedevents.com/speaker-profile/eimear-e-kenny |access-date=2024-06-09 |website=www.emedevents.com}}</ref> As one example, she and her colleagues investigated genetic disorders that might be under-diagnosed due to insufficient data. In the study, they found a mutation in a collagen gene associated with [[Steal syndrome|Steel syndrome]]. This syndrome caused short stature and bone and joint issues and was once thought to be rare. However, the study revealed it is quite common in individuals with [[Puerto Ricans|Puerto Rican]] ancestry.<ref>{{Cite web |last= |first= |last2= |last3= |date=2023-10-26 |title=Improving diversity in the genomics field |url=https://www.hsph.harvard.edu/news/features/program-in-quantitative-genomics-conference-improving-diversity-in-the-genomics-field/ |access-date=2024-06-10 |website=Harvard School of Public Health |language=en-us}}</ref>
Her research includes medicine [[genomics]] and [[computer science]], with a focus on population computational approaches for genomics, precision medicine, and statistical genetics.<ref>{{Cite web |title=Dr. Eimear Kenny – H3Africa |url=https://h3africa.org/index.php/consortium/independent-expert-committee/dr-eimear-kenny/ |access-date=2024-06-09 |language=en-US}}</ref> The intent is to generate progress in understanding the impact of human genetic variation and advancing the use of genomic information in routine clinical care for diverse populations. She also works to improve diversity in genomic research intended to lessen health disparities in global genomic medicine.<ref>{{Cite web |title=Eimear Kenny, PhD - AMP2022 |url=https://amp22.amp.org/program/speakers/eimear-kenny/ |access-date=2024-06-09 |website=amp22.amp.org}}</ref> Three of Kenny's genomic medicine clinical trials assessed how to bring new technology, such as digital apps, or information, such as [[Polygene|polygenic]] risk scores, into routine clinical care.<ref name=":0" />
Kenny, in 2023, was one of the scientists who aided in a “landmark” breakthrough in genomics by mapping genomic codes of a diverse group of people, shifting the science from a single genetic code into a pangenome that maps a diverse group of people. Previously, the only genetic map used in science was based on one man in [[Buffalo, New York|Buffalo]] of European and African descent. [[The Washington Post]] reported that this “more diverse human genome offers hope for rare genetic diseases.”<ref>{{Cite web |date=2023-05-10 |title=Scientists announce rough draft of human pangenome |url=https://www.nbcnews.com/science/science-news/scientists-announce-rough-draft-human-pangenome-rcna83120 |access-date=2024-06-10 |website=NBC News |language=en}}</ref><ref>{{Cite web |last=Press |first=LAURA UNGAR Associated |date=2023-05-10 |title='Pangenome,' a new DNA reference, will reflect human diversity |url=https://www.latimes.com/science/story/2023-05-10/dna-reference-guide-expanded-to-reflect-human-diversity |access-date=2024-06-10 |website=Los Angeles Times |language=en-US}}</ref>
'''''<u>[PHASE TWO ELEMENTS SHOULD INCLUDE:]</u>'''''
=== Novel findings ===
(Select findings to list and back them up with papers or abstracts that can be found on PubMed)
== Other work ==
''This is where we can use some sources that don't specifically mention Dr. Kenny or exclusively center on Dr. Kenny, and probably should be on other pages, but we can spin them:''
•Government Briefings
•Smithsonian
•1000 Genomes Project
•H3Africa
• MIEHR, 10-Year Strategic Plan, AoURP, International Genome Sample Resource, eMERGE, PRIMED, CSER, GSP, TOPMed, PAGE, and HPRC, etc.
'''''<u>[END OF PHASE 2 ELEMENTS]</u>'''''
=== Patents and licenses ===
'''[<u>''Are there patent numbers for these? Or patent names that I can look up?]''</u>'''
'''License holder for Random Forest adMIXture (RFMix)''' Kenny was co-developer and current license holder for RFMix, a software for inferring continental and sub-continental ancestry at genomic [[Locus (mathematics)|loci]]. (''[[Stanford University]]'')
'''License holder for GUÍA''' Kenny is co-developer and inventor of GUÍA,<ref>{{Cite web |title=GUÍA - Home |url=https://www.guiagenomics.com/ |access-date=2024-06-10 |website=www.guiagenomics.com}}</ref> a bilingual (Spanish and English) digital health app to facilitate communication of personalized genetic test results to patients and families. (''Under review at technology office, Mount Sinai, 2024)''
'''License holder for GenomeDiver''' Kenny is co-developer and inventor of GenomeDiver,<ref>{{Cite web |title=GenomeDiver |url=https://genomediver.org/index.html#about |access-date=2024-06-10 |website=genomediver.org}}</ref> a digital health app to enhance the ability of clinicians to diagnose genetic conditions by facilitating dialoge between clinical testing laboratories and clinical care teams (''Under review at technology office, Mount Sinai, 2024)''
=== Clinical trials ===
''Ranked #24* NIH-funded Genetics Investigator in the US in 2020 (Blue Ridge Rankings)''
''Ranked #16 NIH-funded Genetics Investigator in the US in 2019 (Blue Ridge Rankings)''
''Ranked #17 NIH-funded Genetics Investigator in the US in 2018 (Blue Ridge Rankings)''
''Ranked #27 NIH-funded Genetics Investigator in the US in 2017 (Blue Ridge Rankings)''
As of 2024 Top 20 funded genetics researcher (Blueridge); driving basic and clinical research programs at the interface of computer science, genomics, medicine, and health equity. Current trails as of 2024 include:
'''<u>''[Blueridge backup to these claims only appear in Excel files; not applicable to Wikipedia sourcing standards - ideas on where to find backup?]''</u>'''
{| class="wikitable"
| colspan="2" |'''MPI'''
| colspan="2" |[[National Human Genome Research Institute|NHGRI]]
| colspan="2" |U01 HG011715<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/gZuPGyxG7kyoHrqNpGG63Q/project-details/10424501 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Pasanuic, Kenny, Lange): ''PRS Center for Admixed Populations and health Equity (CAPE).'' (06/08/2021-03/31/2026). ''Prime: UCLA''
|-
| colspan="2" |'''MPI'''
| colspan="2" |NHGRI
| colspan="2" |R01 HG011345<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/x1sl_5FgwUKXM5s9d3TV0w/project-details/10676210 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Gignoux, Kenny, Zaitlen, Arboleda): ''Genomic Approaches to Population Health in Multi-Ethnic Hospital Systems (09/01/2020-08/31/2025). Prime: Colorado''
|-
| colspan="2"|'''Contact-PI, MPI'''
| colspan="2" |NHGRI
| colspan="2" |U01 HG011176<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/4lJ-_l783UCPryLfBb3NyQ/project-details/10657565 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Kenny, Abul-Husn): ''Genomic risk in clinical care to promote health equity in New York City patients. (07/01/2020-03/31/2025).''
|-
|colspan="2"|'''Contact-PI, MPI'''
|colspan="2"|NHGRI
|colspan="2" |U01 HG011176-04S2<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/7rTwIrBtiUi99HhQ-7l4IA/project-details/10835330 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Kenny, Soper, Iverson): Genomic risk in clinical care to promote health equity in New York City patients : Medical Education Supplement (04/1/2024-03/31/2025)
|-
|'''Contact-PI, MPI'''
| colspan="4" |NHGRI
|U01 HG011176-04S1<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/oEk8tUSXCEi1lfJWa2YO6A/projects |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Kenny, Abul-husn): Genomic risk in clinical care to promote health equity in New York City patients : Diverse Recruitment Supplement (04/1/2024-03/31/2025)
|-
|'''MPI'''
| colspan="4" |NHGRI
|U01 HG010971<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/txA_HOcmCE6j1JGaAdFEgA/project-details/10020424 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Miga, Eichler, Jarvis, Kenny, Wang): ''Center for Human Reference Genomic Diversity (08/01/2019-07/31/2024) Prime: UCSC''
|-
|'''MPI'''
| colspan="4" |[[National Heart, Lung, and Blood Institute|NHLBI]]
|R01 HL104608<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/ss9byZFMwke199567kPxNw/project-details/10326791 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Barnes, Kenny, Mathais): ''New Approaches for Empowering Studies of Asthma in Populations of African Descent (01/01/2018-11/30/2023) Prime: U. Colorado''
|-
| colspan="2" |'''Co-I'''
| colspan="2" |NHLBI
| colspan="2" |R01 HL151152<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/fS_K7aXSe06XT7RCEEp_Uw/project-details/10673171 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Kooperberg, North, Gignoux): ''Polygenic Risk Scores for Diverse Populations – Bridging Research and Clinical Care''. ''(09/01/2020-08/31/2025). Prime: Fred Hutchinson''
|-
|colspan="2"|'''Co-I'''
|colspan="2"|NHGRI
|colspan="2" |R01 HG010297<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/UgqJQasySUSqliX5EyaxdA/project-details/10135132 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Matisse, Gignoux): ''PAGE III: Population Architecture using Genomics and Epidemiology (06/15/2019-03/31/2023) Prime: Rutgers''
|-
| colspan="2" |'''Co-I'''
| colspan="2" |NHLBI
| colspan="2" |R01 HL155356<ref>{{Cite web |title=RePORT ⟩ RePORTER |url=https://reporter.nih.gov/search/jxTYLpZzZkyzlzp6q-8OsQ/project-details/10100303 |access-date=2024-06-09 |website=reporter.nih.gov}}</ref> (Abul-husn, Kontorovich): ''Uncovering early signals of hereditary TTR amyloidosis in minority populations at high genetic risk (09/01/2020-08/31/2025).''
|}
=Education and career =
Kenny graduated from [[Trinity College Dublin]] with a BA in Biochemistry in 1999 and medical residency at [[University of Leeds|Leeds University]]. She received her PhD in Computational Genomics at [[Rockefeller University]].<ref>{{Cite web |title=STAGE ISSS: Eimear Kenny |url=https://canssiontario.utoronto.ca/event/stage-isss-eimear-kenny/ |access-date=2024-06-10 |website=canssiontario.utoronto.ca}}</ref><ref>{{Cite web |date=2022-10-05 |title=Eimear Kenny {{!}} Irish America |url=https://www.irishamerica.com/honoree/eimear-kenny-2/ |access-date=2024-06-10 |language=en-US}}</ref> '''<u>''[Stanford? It's mentioned online. Perhaps it does not belong here.]''</u>'''
=== Academic appointments ===
As of 2024, at Mount Sinai, she serves as the Endowed Chair and Professor of Genomic Health, Professor at the Department of Medicine, Division of General Internal Medicine, and Professor at the Department of Genetics and Genomic Sciences. She is also the executive chair of the New York area population and medical genomics group at the [[New York Genome Center]].<ref>{{Cite web |last=Anderson |first=William |date=2022-07-20 |title=ASHG Honors Eimear Kenny, PhD with the 2022 Early-Career Award |url=https://www.ashg.org/publications-news/ashg-news/202207-early-career-award/ |access-date=2024-06-10 |website=ASHG |language=en-US}}</ref>
Former appointments include Assistant Professor at the Department of Genetics and Genomic Sciences and Member at The Charles Bronfman Institute of Personalized Medicine, both at Mount Sinai. She was also Bioinformatics Programmer at the [[California Institute of Technology]].<ref>{{Cite web |title=ORCID |url=https://orcid.org/0000-0001-9198-759X |access-date=2024-06-10 |website=orcid.org}}</ref>
=== Honors and awards ===
'''<u>''[Note: one typical push back from other editors is when a biographical articles start to look like like a CV. Generally, it's good to avoid any honors or awards that were presented by (a) employer, and (b) former school or university. We nominate this section for deletion.]''</u>'''
{| class="wikitable"
|'''2022'''
|Irish American Magazine Top 50 in Healthcare and Life Sciences (USA)
|-
|'''2022'''
|Early-Career Award, American Society of Human Genetics (USA)<ref>{{Cite web |last=Md 20852 |title=Past Award Recipients |url=https://www.ashg.org/membership/awards/past-recipients/ |access-date=2024-06-09 |website=ASHG |language=en-US}}</ref>
|-
|'''2018'''
|Faculty Council Junior Faculty Achievement Award, Mount Sinai Health System
|-
|'''2016'''
|Irish Educator, awardee (New York)
|-
|'''2012'''
|Postdoc Poster Finalist, 20<sup>th</sup> Annual Society of Molecular Biology and Evolution Meeting (Ireland)
|-
|'''2010'''
|Graduate Student Epstein Award Semifinalist, 60<sup>th</sup> Annual American Society of Human Genetics Meeting (Washington DC)
|-
|'''2009'''
|Graduate Student Research Poster Finalist, 11<sup>th</sup> International Meeting on Human Genome Variation and Complex Genome Analysis (Estonia)
|-
|'''2007-2010'''
|Women and Science Pre-doctoral Fellowship, Rockefeller University (New York)
|}
=Publications =
=== Editorial Boards ===
As of 2024, Kenny is an advisor to Cell Genomics,<ref>{{Cite web |title=Advisory Board, Cell Genomics |url=https://www.cell.com/cell-genomics/advisory-board |access-date=June 9, 2024 |website=Cell Genomics}}</ref> associate editor for the [[American Journal of Human Genetics]],{{Citation needed|date=June 2024}} and on the editorial boards of Frontiers in Evolutionary and Population Genetics.{{Citation needed|date=June 2024}}
=== Articles ===
As of 2024, [[Google Scholar]] reports 43,096 citations, an h-index of 57 and an i10-index of 117. The five most-cited articles she contributed to are:
* 1000 Genomes Project Consortium; Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR. ''A global reference for human genetic variation''. Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393. {{PMID|26432245}}; PMCID: PMC4750478. Cited by 14847<ref>{{Cite web |title=A global reference for human genetic variation |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=ObdsXj8AAAAJ&citation_for_view=ObdsXj8AAAAJ:86PQX7AUzd4C |access-date=2024-06-09 |website=scholar.google.com}}</ref>
* 1000 Genomes Project Consortium; Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. ''An integrated map of genetic variation from 1,092 human genomes''. Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. {{PMID|23128226}}; PMCID: PMC3498066. Cited by 8287<ref>{{Cite web |title=An integrated map of genetic variation from 1,092 human genomes |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=ObdsXj8AAAAJ&citation_for_view=ObdsXj8AAAAJ:qxL8FJ1GzNcC |access-date=2024-06-09 |website=scholar.google.com}}</ref>
* Jacob A. Tennessen et al. ''Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes''.Science337,64-69(2012).DOI:10.1126/science.1219240 Cited by 1886<ref>{{Cite journal |last=Tennessen |first=Jacob A. |last2=Bigham |first2=Abigail W. |last3=O’Connor |first3=Timothy D. |last4=Fu |first4=Wenqing |last5=Kenny |first5=Eimear E. |last6=Gravel |first6=Simon |last7=McGee |first7=Sean |last8=Do |first8=Ron |last9=Liu |first9=Xiaoming |last10=Jun |first10=Goo |last11=Kang |first11=Hyun Min |last12=Jordan |first12=Daniel |last13=Leal |first13=Suzanne M. |last14=Gabriel |first14=Stacey |last15=Rieder |first15=Mark J. |date=2012-07-06 |title=Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes |url=https://www.science.org/doi/10.1126/science.1219240 |journal=Science |language=en |volume=337 |issue=6090 |pages=64–69 |doi=10.1126/science.1219240 |issn=0036-8075}}</ref>
* Taliun, D., Harris, D.N., Kessler, M.D. et al. ''Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program''. Nature 590, 290–299 (2021). https://doi.org/10.1038/s41586-021-03205-y Cited by 1369<ref>{{Cite web |title=Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=ObdsXj8AAAAJ&citation_for_view=ObdsXj8AAAAJ:1sJd4Hv_s6UC |access-date=2024-06-09 |website=scholar.google.com}}</ref>
* Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; ''Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study''; Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL. ''Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores''. Am J Hum Genet. 2015 Oct 1;97(4):576-92. doi: 10.1016/j.ajhg.2015.09.001. {{PMID|26430803}}; PMCID: PMC4596916. Cited by 1327<ref>{{Cite web |title=Modeling linkage disequilibrium increases accuracy of polygenic risk scores |url=https://scholar.google.com/citations?view_op=view_citation&hl=en&user=ObdsXj8AAAAJ&citation_for_view=ObdsXj8AAAAJ:R3hNpaxXUhUC |access-date=2024-06-09 |website=scholar.google.com}}</ref>
==References==
{{Reflist}}
== External links ==
* [http://www.mountsinai.org Mount Sinai Hospital homepage]
* [http://icahn.mssm.edu Icahn School of Medicine at Mount Sinai homepage]
{{Authority control}}
{{Medicine}}
{{Mount Sinai Health System}}
{{DEFAULTSORT:Kenny, Eimear}}
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