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{{short description|Drag}}
{{short description|Technique that temporarily takes over the function of the heart and lungs during surgery}}
In [[fluid dynamics]], '''drag,''' sometimes referred to as '''fluid resistance,''' is a [[force]] acting opposite to the relative motion of any object moving with respect to a surrounding fluid.<ref>{{cite web |title=Definition of DRAG |url=http://www.merriam-webster.com/dictionary/drag |access-date=2023-05-07 |website=Merriam-Webster}}</ref> This can exist between two fluid layers (or surfaces), or between a fluid and a [[solid]] surface. Drag forces always tend to decrease fluid velocity relative to the solid object in the fluid's path.
{{Infobox medical intervention|Name=Cardiopulmonary bypass|Image=Coronary artery bypass surgery Image_657C-PH.jpg|Caption=A heart–lung machine (upper right) in a [[coronary artery bypass surgery]].|ICD10=12|ICD9={{ICD9proc|39.61}}|MeshID=D002318|OPS301=14|OtherCodes=22570829}}


Unlike other resistive forces, '''drag force''' depends on velocity.<ref>French (1970), p. 211, Eq. 7-20</ref><ref name="NASAdrag">{{cite web |title=What is Drag? |url=http://www.grc.nasa.gov/WWW/k-12/airplane/drag1.html |url-status=dead |archive-url=https://web.archive.org/web/20100524003905/http://www.grc.nasa.gov/WWW/K-12/airplane/drag1.html |archive-date=2010-05-24 |access-date=2011-10-16}}</ref> Drag force is proportional to the velocity for low-speed flow and the squared velocity for high speed flow. This distinction between low and high speed flow is measured by the [[Reynolds number]].
== Summary ==
'''Cardiopulmonary Bypass''' ('''CPB''') is a machine that temporarily takes over the function of the [[heart]] and [[Lung|lungs]] during a [[cardiac surgery]] by maintaining the circulation of blood and oxygen throughout the body.<ref name="Raja.9">{{cite book |title=Cardiac Surgery: A Complete Guide |vauthors=Stefanou D, Dimarakis I |date=2020 |publisher=Springer |isbn=978-3-030-24176-6 |veditors=Raja SG |location=Switzerland |pages=93–99 |language=en |chapter=9. Adult cardiopulmonary bypass |chapter-url=https://books.google.com/books?id=kcPPDwAAQBAJ&pg=PA93}}</ref>


== Examples ==
CPB is used during many heart surgeries to improve the safety of the patient during a heart procedure. The machine mechanically circulates and oxygenates blood throughout the patient's body while bypassing the heart and lungs. Additionally, it maintains perfusion to other body organs and tissues of the patient while the surgeon works in a bloodless surgical field.
Examples of drag include the component of the [[Net force|net]] [[Aerodynamic force|aerodynamic]] or [[Hydrodynamics|hydrodynamic]] [[force]], acting opposite to the direction of movement of a solid object such as cars ([[automobile drag coefficient]]), aircraft<ref name="NASAdrag" /> and boat hulls. Moreover, acting in the same geographical direction of motion as the solid, as for sails attached to a down wind sail boat, or in intermediate directions on a sail depending on points of sail.<ref name="Eiffel">{{cite book |last=Eiffel |first=Gustave |title=The Resistance of The Air and Aviation |publisher=Constable &Co Ltd |year=1913 |location=London}}</ref><ref name="Marchaj1">{{cite book |last=Marchaj |first=C. A. |title=Sail performance : techniques to maximise sail power |publisher=Adlard Coles Nautical |year=2003 |isbn=978-0-7136-6407-2 |edition=Rev. |location=London |pages=147 figure 127 lift vs drag polar curves}}</ref><ref name="Fossati1">{{cite book |last=Drayton |first=Fabio Fossati; translated by Martyn |title=Aero-hydrodynamics and the performance of sailing yachts : the science behind sailing yachts and their design |publisher=International Marine /McGraw-Hill |year=2009 |isbn=978-0-07-162910-2 |location=Camden, Maine |pages=98 Fig 5.17 Chapter five Sailing Boat Aerodynamics}}</ref> In the case of viscous drag of [[Laminar flow|fluid in a pipe]], drag force on the immobile pipe decreases fluid velocity relative to the pipe.<ref name="Fowler">{{cite web |title=Calculating Viscous Flow: Velocity Profiles in Rivers and Pipes |url=http://galileo.phys.virginia.edu/classes/152.mf1i.spring02/RiverViscosity.pdf |access-date=16 October 2011}}</ref><ref>{{cite web |title=Viscous Drag Forces |url=http://www.ce.utexas.edu/prof/kinnas/319LAB/Applets/Viscous/viscous.html |access-date=16 October 2011}}</ref>


In the physics of sports, the drag force is necessary to explain the motion of balls, javelins, arrows and frisbees and the performance of runners and swimmers.<ref>{{cite journal |last1=Hernandez-Gomez |first1=J J |last2=Marquina |first2=V |last3=Gomez |first3=R W |date=25 July 2013 |title=On the performance of Usain Bolt in the 100 m sprint |url=https://www.researchgate.net/publication/236858493 |journal=Eur. J. Phys. |volume=34 |issue=5 |pages=1227–1233 |arxiv=1305.3947 |bibcode=2013EJPh...34.1227H |doi=10.1088/0143-0807/34/5/1227 |s2cid=118693492 |access-date=23 April 2016}}</ref>
The CPB is often referred to as a '''heart-lung machine,''' "the pump," or CPB pumps. CPB is operated by [[Perfusionist|perfusionists]], and is a form of[[extracorporeal]] circulation.


== History ==
== ==
{| class="wikitable floatright" style="text-align: center;"
[[File:1955_heart_lung_machine.jpg|right|thumb|A heart lung machine used in London's [[Middlesex Hospital]] in 1958. [[Science Museum, London]] (2008)]]
!Shape and flow
[[File:Cardiopulmonary_bypass_machine.jpg|thumb|Cardiopulmonary bypass machine used at the University of Michigan in the 1960s.]]
!Form
[[File:Patent_autojektor.gif|right|thumb|Brukhonenko's ''Autojektor'']]
Drag
The Austrian-German physiologist [[Maximilian von Frey]] constructed an early prototype of a heart-lung machine in 1885. This was conducted at [[Carl Ludwig]]'s Physiological Institute of the [[University of Leipzig]].<ref>{{cite journal |vauthors=Zimmer HG |date=September 2003 |title=The heart-lung machine was invented twice--the first time by Max von Frey |journal=Clinical Cardiology |volume=26 |issue=9 |pages=443–445 |doi=10.1002/clc.4960260914 |pmc=6654655 |pmid=14524605}}</ref> However, such machines were not feasible before the discovery of [[heparin]] in 1916, which prevents blood [[coagulation]]. The Soviet scientist [[Sergei Brukhonenko]] developed a heart-lung machine for total body perfusion in 1926 named the ''Autojektor'', which was used in experiments with canines, some of which were showcased in the 1940 film ''[[Experiments in the Revival of Organisms]]''. A team of scientists at the [[University of Birmingham]] (including Eric Charles, a chemical engineer) were among the pioneers of this technology.<ref>{{cite journal |display-authors=6 |vauthors=Dennis C, Spreng DS, Nelson GE, Karlson KE, Nelson RM, Thomas JV, Eder WP, Varco RL |date=October 1951 |title=Development of a pump-oxygenator to replace the heart and lungs; an apparatus applicable to human patients, and application to one case |journal=Annals of Surgery |volume=134 |issue=4 |pages=709–721 |doi=10.1097/00000658-195110000-00017 |pmc=1802968 |pmid=14878382}}</ref><ref>{{cite book |url=https://archive.org/details/bub_gb_pCEDAAAAMBAJ |title=Popular Science |date=1 February 1951 |publisher=Bonnier Corporation |page=[https://archive.org/details/bub_gb_pCEDAAAAMBAJ/page/n105 4] |access-date=4 April 2018 |via=Internet Archive}}</ref>
!Skin
friction
|-
|[[File:Flow_plate.svg|94x94px]]
|≈0%
|≈100%
|-
|[[File:Flow_foil.svg|94x94px]]
|≈10%
|≈90%
|-
|[[File:Flow_sphere.svg|94x94px]]
|≈90%
|≈10%
|-
|[[File:Flow_plate_perpendicular.svg|94x94px]]
|≈100%
|≈0%
|}
Types of drag are generally divided into the following categories:


* [[form drag]] or [[pressure drag]] due to the size and shape of a body
Dr. [[Clarence Dennis]] led the team at the [[University of Minnesota Medical Center]] that on April 5, 1951, conducted the first human operation involving open cardiotomy with temporary mechanical takeover of both heart and lung functions. The patient did not survive due to an unexpected complex congenital heart defect. One member of the team was Dr. [[Russell M. Nelson]], who later became [[President of the Church (LDS Church)|president]] of [[the Church of Jesus Christ of Latter-day Saints]] and who performed the first open heart surgery in [[Utah]].<ref>{{cite web |title=U of U Health - Celebrating 60 Years of Cardiac Surgery in Utah With Russell M. Nelson, M.D. |url=https://healthcare.utah.edu/publicaffairs/news/2015/Russell_Nelson_60_heart_anniversary.php |url-status=dead |archive-url=https://web.archive.org/web/20180117131234/https://healthcare.utah.edu/publicaffairs/news/2015/Russell_Nelson_60_heart_anniversary.php |archive-date=17 January 2018 |access-date=4 April 2018 |website=utah.edu}}</ref>
* [[skin friction drag]] or [[viscous drag]] due to the friction between the fluid and a surface which may be the outside of an object or inside such as the bore of a pipe


The effect of streamlining on the relative proportions of skin friction and form drag is shown for two different body sections, an airfoil, which is a streamlined body, and a cylinder, which is a bluff body. Also shown is a flat plate illustrating the effect that orientation has on the relative proportions of skin friction and pressure difference between front and back. A body is known as bluff (or blunt) if the source of drag is dominated by pressure forces and streamlined if the drag is dominated by viscous forces. Road vehicles are bluff bodies.<ref>Encyclopedia of Automotive Engineering, David Crolla, Paper "Fundamentals, Basic principles in Road vehicle Aerodynamics and Design", {{ISBN|978 0 470 97402 5}}</ref> For aircraft, pressure and friction drag are included in the definition of [[parasitic drag]]. Parasite drag is often expressed in terms of a hypothetical (in so far as there is no edge spillage drag<ref>The Design Of The Aeroplane, Darrol Stinton, {{ISBN|0 632 01877 1}}, p.204</ref>) "equivalent parasite drag area" which is the area of a flat plate perpendicular to the flow. It is used for comparing the drag of different aircraft. For example, the [[Douglas DC-3]] has an equivalent parasite area of 23.7 sq ft and the [[McDonnell Douglas DC-9]], with 30 years of advancement in aircraft design, an area of 20.6 sq ft although it carried five times as many passengers.<ref>Fundamentals of Flight, Second Edition, Richard S. Shevell,{{ISBN|0 13 339060 8}}, p.185</ref>
The first successful mechanical support of left ventricular function was performed on July 3, 1952, by [[Forest Dewey Dodrill]] using a machine co-developed with General Motors, the [[Dodrill-GMR]]. The machine was later used to support right ventricular function.<ref>{{cite book |url=https://archive.org/details/surgerybasicscie00nort |title=Surgery: Basic science and clinical evidence |vauthors=Norton J |publisher=springer |year=2008 |isbn=978-0-387-30800-5 |location=NY |pages=[https://archive.org/details/surgerybasicscie00nort/page/n1473 1473] |url-access=limited}}</ref>


* [[lift-induced drag]] appears with [[Wing|wings]] or a [[lifting body]] in aviation and with semi-planing or [[Planing hull|planing hulls]] for [[watercraft]]
The first successful open heart procedure on a human utilizing the heart lung machine was performed by [[John Heysham Gibbon|John Gibbon]] and Frank F. Allbritten, Jr.<ref>{{cite journal |vauthors=Hedlund KD |date=2001 |title=A Tribute to Frank F Alibritten, Jr. Origin of the left ventricular vent during the early years of open-heart surgery with the Gibbon heart-lung machine |journal=Texas Heart Institute Journal |volume=28 |issue=4 |pages=292–296 |pmc=101205 |pmid=11777154}}</ref> on May 6, 1953, at [[Thomas Jefferson University Hospital]] in [[Philadelphia]]. They repaired an [[atrial septal defect]] in an 18-year-old woman.<ref>{{cite journal |vauthors=Cohn LH |date=May 2003 |title=Fifty years of open-heart surgery |journal=Circulation |volume=107 |issue=17 |pages=2168–2170 |doi=10.1161/01.CIR.0000071746.50876.E2 |pmid=12732590 |doi-access=free}}</ref> Gibbon's machine was further developed into a reliable instrument by a surgical team led by [[John W. Kirklin]] at the [[Mayo Clinic]] in [[Rochester, Minnesota]] in the mid-1950s.<ref>"[https://www.uab.edu/newsarchive/42933-john-kirklin-cardiac-surgery-pioneer-dead-at-age-86 John Kirklin Cardiac Surgery Pioneer Dead at Age 86]." (April 23, 2004) University of Alabama at Birmingham. press release</ref>
* [[wave drag]] ([[aerodynamics]]) is caused by the presence of shockwaves and first appears at subsonic aircraft speeds when local flow velocities become supersonic. The wave drag of the supersonic [[Concorde]] prototype aircraft was reduced at Mach 2 by 1.8% by applying the [[area rule]] which extended the rear fuselage 3.73m on the production aircraft.<ref>A Case Study By Aerospatiale And British Aerospace On The Concorde By Jean Rech and Clive S. Leyman, AIAA Professional Study Series, Fig. 3.6</ref>
* [[Wave-making resistance|wave resistance]] (ship hydrodynamics) or [[wave drag]] occurs when a solid object is moving along a fluid boundary and making [[Ocean surface wave|surface waves]]
* boat-tail drag on an aircraft is caused by the angle with which the rear fuselage, or engine nacelle, narrows to the engine exhaust diameter.<ref>Design For Air Combat, Ray Whitford,{{ISBN|0 7106 0426 2}}, p.212</ref>


== Drag Equation ==
The oxygenator was first conceptualized in the 17th century by [[Robert Hooke]] and developed into practical extracorporeal oxygenators by French and German experimental physiologists in the 19th century. Bubble oxygenators have no intervening barrier between blood and oxygen, these are called 'direct contact' oxygenators. Membrane oxygenators introduce a gas-permeable membrane between blood and oxygen that decreases the [[Clotting|blood trauma]] of direct-contact oxygenators. Much work since the 1960s focused on overcoming the gas exchange handicap of the membrane barrier, leading to the development of high-performance microporous hollow-fibre oxygenators that eventually replaced direct-contact oxygenators in cardiac theatres.<ref name="Lim 2006">{{cite journal |vauthors=Lim MW |date=October 2006 |title=The history of extracorporeal oxygenators |journal=Anaesthesia |volume=61 |issue=10 |pages=984–995 |doi=10.1111/j.1365-2044.2006.04781.x |pmid=16978315 |s2cid=24970815 |doi-access=}}</ref>
[[File:Drag_coefficient_on_a_sphere_vs._Reynolds_number_-_main_trends.svg|thumb|Drag coefficient ''C''<sub>d</sub> for a sphere as a function of [[Reynolds number]] ''Re'', as obtained from laboratory experiments. The dark line is for a sphere with a smooth surface, while the lighter line is for the case of a rough surface.]]
Drag depends on the properties of the fluid as well as the size, shape, and speed of the object. One way to express this concept is through the [[drag equation]]:<math display="block">F_D\, =\, \tfrac12\, \rho\, v^2\, C_D\, A</math>Key:


* <math>F_D</math> is the '''drag force''',
In 1983, Ken Litzie patented a closed emergency heart bypass system which reduced circuit and component complexity.<ref>{{Cite patent|country=US|number=4540399|title=US Patent for Emergency bypass system|gdate=10 September 1985|inventor=Litzie K, Roberts CP|assign1=C.R. Bard, Inc|assign2=Lifestream International, LLC|url=https://patents.justia.com/patent/4540399|postscript=.}}</ref> This device improved patient survival after cardiac arrest because it could be rapidly deployed in non-surgical settings.<ref>{{cite journal |display-authors=6 |vauthors=Reichman RT, Joyo CI, Dembitsky WP, Griffith LD, Adamson RM, Daily PO, Overlie PA, Smith SC, Jaski BE |date=January 1990 |title=Improved patient survival after cardiac arrest using a cardiopulmonary support system |journal=The Annals of Thoracic Surgery |volume=49 |issue=1 |pages=101–105 |doi=10.1016/0003-4975(90)90363-B |pmid=2297254 |doi-access=free}}</ref>
* <math>\rho</math> is the [[density]] of the fluid,<ref>For [[Atmosphere of Earth|Earth's atmosphere]], the air density can be found using the [[barometric formula]]. It is 1.293 kg/m<sup>3</sup> at 0 °C and 1 [[Atmosphere (unit)|atmosphere]].</ref>
* <math>v</math> is the speed of the object relative to the fluid,
* <math>A</math> is the [[Cross section (geometry)|cross sectional area]], and
* <math>C_D</math> is the [[drag coefficient]] – a [[dimensionless number]].


== Technique ==
CPB requires significant planning before surgery. In particular, the cannulation, cooling, and cardio-protective strategies must be coordinated between the [[surgeon]], [[Anesthesiology|anesthesiologist]], [[perfusionist]], and [[Nursing|nursing staff]].<ref name=":0">{{Cite book |title=Cardiopulmonary bypass : a primer |vauthors=Mokadam NA |publisher=[[University of Washington]] |year=2015 |oclc=922073684}}</ref>


The drag coefficient depends on the shape of the object and on the [[Reynolds number]]<math display="block">R_e=\frac{vD}{\nu} = \frac{\rho vD}{\mu},</math>Key:
=== Cannulation Strategy ===
The cannulation strategy varies on several operation-specific and patient-specific details. The typical arterial cannulation involves the placement of a single cannulation within distal [[Aorta|ascending aorta]]. The most simple form on involves placement of a single cannula (known as a dual-stage cannula) passed through the [[right atrium]] and into the [[inferior vena cava]].


* <math>D</math> is the equivalent [[diameter]] <math>D_{e}</math> of the object. For a sphere, <math>D_{e}</math> is the D of the sphere itself.
The surgeon places a [[cannula]] in the right atrium, vena cava, or femoral vein to withdraw blood from the body. The cannula used to return oxygenated blood is usually inserted in the ascending aorta, but it can also be inserted in the femoral artery, axillary artery, or brachiocephalic artery (among others) according to the demand of the surgery.<ref name=":3">{{Cite book |title=Cardiac surgery in the adult |vauthors=Cohn LH |date=2017-08-28 |isbn=978-0-07-184487-1 |edition=Fifth |location=New York |oclc=930496902}}</ref><ref name=":1">{{Cite book |title=Kirklin/Barratt-Boyes cardiac surgery : morphology, diagnostic criteria, natural history, techniques, results, and indications |vauthors=Kouchoukos NT, Kirklin JW |date=2013 |publisher=Elsevier/Saunders |isbn=978-1-4557-4605-7 |edition=4th |location=Philadelphia |oclc=812289395}}</ref> After the cannula is inserted, venous blood is drained from the body by the cannula into a reservoir. This blood is then filtered, cooled or warmed, and oxygenated before it returns to the body through a mechanical pump
* For a rectangular shape cross-section in the motion direction, <math>D_{e} = 1.30 \cdot \frac{(a \cdot b)^{0.625}} {(a+b)^{0.25}}</math>, where a and b are the rectangle edges.
* <math>{\nu}</math> is the [[kinematic viscosity]] of the fluid (equal to the dynamic viscosity <math>{\mu}</math> divided by the density <math>{\rho}</math> ).


At low <math>R_e</math>, <math>C_D</math> is asymptotically proportional to <math>R_e^{-1}</math>. This means that the drag is linearly proportional to the speed, i.e. the drag force on a small sphere moving through a viscous fluid is given by the [[Stokes Law]]:<math display="block">F_{\rm d} = 3 \pi \mu D v</math>At high <math>R_e</math>, <math>C_D</math> is more or less constant and drag will vary as the square of the speed. The graph to the right shows how <math>C_D</math> varies with <math>R_e</math> for the case of a sphere. Since the power needed to overcome the drag force is the product of the force times speed, the power needed to overcome drag will vary as the square of the speed at low Reynolds numbers and as the cube of the speed at high numbers.
=== Intra-operative Technique ===
A CPB circuit must be primed with fluid and all air expunged from the arterial line/cannula before connection to the patient. The circuit is primed with a [[Crystalloids|crystalloid]] solution and blood products are added if needed. Prior to the cannulation (typically after opening the pericardium when using central cannulation), [[heparin]] or another [[anticoagulant]] is administered until the [[activated clotting time]] is above 480 seconds.<ref name=":1" />


It can be demonstrated that drag force can be expressed as a function of a dimensionless number, which is dimensionally identical to the [[Bejan number]].<ref name="Liversage2018">Liversage, P., and Trancossi, M. (2018). "[http://www.iieta.org/sites/default/files/Journals/MMC/MMC_B/87.03_11.pdf Analysis of triangular sharkskin profiles according to second law]", ''Modelling, Measurement and Control B''. 87(3), 188-196.</ref> Consequently, drag force and drag coefficient can be a function of Bejan number. In fact, from the expression of [[drag force]] it has been obtained:<math display="block">F_{\rm d} = \Delta_p A_w = \frac{1}{2} C_D A_f \frac {\nu \mu}{l^2}Re_L^2</math>and consequently allows expressing the drag [[coefficient]] <math>C_D</math> as a function of [[Bejan number]] and the ratio between wet area <math>A_w</math> and front area <math>A_f</math>:<ref name="Liversage2018" /><math display="block">C_D = 2\frac{A_w}{A_f}\frac{Be}{Re_L^2}</math>where <math>Re_L</math>is the Reynolds number related to fluid path length L.
The arterial cannulation site is inspected for [[calcification]] or other diseases. Pre-operative imaging, or an [[ultrasound]] probe may be used to help identify aortic calcifications that could potentially become dislodged (this can cause an occlusion or [[stroke|stroke)]]. Once the cannulation site has been deemed as safe, two concentric, diamond-shaped [[purse string]] sutures are placed in the distal ascending aorta. A stab incision with a [[scalpel]] is made within the pursestrings and the arterial cannula is passed through the incision.


== At High Velocity ==
It is important the cannula is passed perpendicular to the aorta to avoid creating an [[aortic dissection]].<ref name=":1" /> The purse strings sutures are cinched around the cannula using a tourniquet and secured to the cannula.<ref name=":0" /> At this point, the perfusionist advances the arterial line of the CPB circuit and the surgeon connects the arterial line coming from the patient to the arterial line coming from the CPB machine. Care must be taken to ensure no air is in the circuit when the two are connected, or else the patient could develop an [[air embolism]].<ref name=":2" /><ref name=":1" /> Other sites for arterial cannulation include the [[axillary artery]], [[brachiocephalic artery]], or [[femoral artery]].
{{main|Drag equation}}
[[File:194144main_022_drag.ogv|thumb|320x320px|Explanation of drag by [[NASA]].]]
As mentioned, the [[drag equation]] with a constant drag coefficient gives the force experienced by an object moving through a [[fluid]] at relatively large velocity (i.e. high [[Reynolds number]], Re&nbsp;>&nbsp;~1000). This is also called ''quadratic drag''. The equation is attributed to [[Lord Rayleigh]], who originally used ''L''<sup>2</sup> in place of ''A'' (''L'' being some length).<math display="block">F_D\, =\, \tfrac12\, \rho\, v^2\, C_d\, A,</math>The derivation of this equation is presented at {{slink|Drag equation#Derivation}}.


The reference area ''A'' is often [[orthographic projection]] of the object (frontal area)—on a plane perpendicular to the direction of motion—e.g. for objects with a simple shape, such as a sphere, this is the [[Cross section (geometry)|cross sectional]] area. Sometimes a body is a composite of different parts, each with a different reference areas, in which case a drag coefficient corresponding to each of those different areas must be determined.
Aside from the difference in location, [[Vein|venous]] cannulation is performed similarly to arterial cannulation. Since calcification of the [[Vein|venous system]] is less common, the inspection or use of an ultrasound for calcification at the cannulation sites is unnecessary. Also, because the venous system is under much less pressure than the arterial system, only a single suture is required to hold the cannula in place.<ref name=":1" /> If only a single cannula is to be used (dual-stage cannulation), it is passed through the [[right atrial appendage]], through the tricuspid valve, and into the inferior vena cava.<ref name=":2" /> If two cannula are required (single-stage cannulation), the first one is typically passed through the superior vena cava and the second through the inferior vena cava.<ref name=":2" /> The [[femoral vein]] may also be cannulated in select patients.


In the case of a wing the reference areas are the same and the drag force is in the same ratio to the [[Lift (force)|lift force]] as the ratio of drag coefficient to [[lift coefficient]].<ref>[https://www1.grc.nasa.gov/beginners-guide-to-aeronautics/foilsim/ ''Size effects on drag''] {{Webarchive|url=https://web.archive.org/web/20161109102323/http://www.grc.nasa.gov/WWW/K-12/airplane/sized.html|date=2016-11-09}}, from NASA Glenn Research Center.</ref> Therefore, the reference for a wing is often the lifting area ("wing area") rather than the frontal area.<ref>[https://www1.grc.nasa.gov/beginners-guide-to-aeronautics/wing-geometry-interactive/ ''Wing geometry definitions''] {{Webarchive|url=https://web.archive.org/web/20110307125108/http://www.grc.nasa.gov/WWW/k-12/airplane/geom.html|date=2011-03-07}}, from NASA Glenn Research Center.</ref>
If the heart must be stopped for the operation, [[cardioplegia]] cannulas are also required. Antegrade cardioplegia (forward flowing, through the heart's arteries), retrograde cardioplegia (backwards flowing, through the heart's veins), or both types may be used depending on the operation and surgeon preference. For antegrade cardioplegia, a small incision is made in the aorta proximal to the arterial cannulation site (between the heart and arterial cannulation site) and the cannula is placed through this to deliver cardioplegia to the [[coronary arteries]]. For retrograde cardioplegia, an incision is made on the posterior (back) surface of the heart through the [[right ventricle]]. The cannula is placed in this incision, passed through the tricuspid valve, and into the [[coronary sinus]].<ref name=":0" /><ref name=":2" /> The cardioplegia lines are connected to the CPB machine.


For an object with a smooth surface, and non-fixed [[Flow separation|separation points]]—like a sphere or circular cylinder—the drag coefficient may vary with Reynolds number ''R<sub>e</sub>'', even up to very high values (''R<sub>e</sub>'' of the [[Order of magnitude|order]] 10<sup>7</sup>).<ref>{{cite journal |last=Roshko |first=Anatol |year=1961 |title=Experiments on the flow past a circular cylinder at very high Reynolds number |url=https://authors.library.caltech.edu/10105/1/ROSjfm61.pdf |journal=Journal of Fluid Mechanics |volume=10 |issue=3 |pages=345–356 |bibcode=1961JFM....10..345R |doi=10.1017/S0022112061000950 |s2cid=11816281}}</ref> <ref name="Batch341">Batchelor (1967), p. 341.</ref> For an object with well-defined fixed separation points, like a circular disk with its plane normal to the flow direction, the drag coefficient is constant for ''R<sub>e</sub>''&nbsp;>&nbsp;3,500.<ref name="Batch341" /> Further the drag coefficient ''C<sub>d</sub>'' is, in general, a function of the orientation of the flow with respect to the object (apart from [[Symmetry|symmetrical]] objects like a sphere).
At this point, the patient is ready to go on bypass. Blood from the venous cannula(s) enters the CPB machine by gravity where it is oxygenated and cooled (if necessary) before returning to the body through the arterial cannula. Cardioplegia can now be administered to stop the heart, and a cross-clamp is placed across the aorta between the arterial cannula and cardioplegia cannula to prevent the arterial blood from flowing backwards into the heart. Setting appropriate blood pressure targets to maintain the health and function of the organs including the brain and kidney are important considerations.<ref>{{Cite journal |last=Kotani |first=Yuki |last2=Kataoka |first2=Yuki |last3=Izawa |first3=Junichi |last4=Fujioka |first4=Shoko |last5=Yoshida |first5=Takuo |last6=Kumasawa |first6=Junji |last7=Kwong |first7=Joey SW |date=2022-11-30 |editor-last=Cochrane Heart Group |title=High versus low blood pressure targets for cardiac surgery while on cardiopulmonary bypass |url=http://doi.wiley.com/10.1002/14651858.CD013494.pub2 |journal=Cochrane Database of Systematic Reviews |language=en |volume=2022 |issue=11 |doi=10.1002/14651858.CD013494.pub2 |pmc=9709767 |pmid=36448514}}</ref>


=== Power ===
Once the patient is ready to come off of bypass support, the cross-clamp and cannulas are removed and [[protamine sulfate]] is administered to reverse the anticoagulative effects of heparin.
Under the assumption that the fluid is not moving relative to the currently used reference system, the [[Power (physics)|power]] required to overcome the aerodynamic drag is given by:<math display="block"> P_d = \mathbf{F}_d \cdot \mathbf{v} = \tfrac12 \rho v^3 A C_d</math>The power needed to push an object through a fluid increases as the cube of the velocity. A car cruising on a highway at {{convert|50|mph|km/h|abbr=on}} may require only {{convert|10|hp|kW|lk=in}} to overcome aerodynamic drag, but that same car at {{convert|100|mph|km/h|abbr=on}} requires {{convert|80|hp|kW|abbr=on}}.<ref>{{citation |author=Brian Beckman |title=Part 6: Speed and Horsepower |date=1991 |url=http://phors.locost7.info/phors06.htm |access-date=18 May 2016 |archive-url=https://web.archive.org/web/20190616063447/http://phors.locost7.info:80/phors06.htm |archive-date=2019-06-16}}</ref> With a doubling of speed the drag (force) quadruples per the formula. Exerting 4 times the force over a fixed distance produces 4 times as much [[Mechanical work|work]]. At twice the speed the work (resulting in displacement over a fixed distance) is done twice as fast. Since power is the rate of doing work, 4 times the work done in half the time requires 8 times the power.


When the fluid is moving relative to the reference system (e.g. a car driving into headwind) the power required to overcome the aerodynamic drag is given by:<math display="block"> P_d = \mathbf{F}_d \cdot \mathbf{v_o} = \tfrac12 C_d A \rho (v_w + v_o)^2 v_o</math>Where <math>v_w</math> is the wind speed and <math>v_o</math> is the object speed (both relative to ground).
== Components ==
Cardiopulmonary bypass devices consist of two main functional units, the [[pump]] and the [[oxygenator]] which removes relatively oxygen-depleted blood from a patient's body and replaces it with oxygen-rich blood through a series of tubes (hoses). A [[heat exchanger]] is used to control body temperature by heating or cooling the blood in the circuit. It is important that all components of the circuit are coated internally by [[heparin]] or another anticoagulant to prevent clotting within the circuit.<ref name=":3" />
[[File:Perfusionist_opearting_heart_lung_machine.jpg|thumb|322x322px|Perfusionist operating a modern heart lung machine]]


=== Tubing ===
=== ===
{{main|Terminal velocity}}
The components of the CPB circuit are interconnected by a series of tubes made of [[silicone rubber]] or [[PVC]].<ref>{{Cite web |title=Cardiopulmonary bypass machine - CPB |url=https://www.ebme.co.uk/articles/clinical-engineering/cardiopulmonary-bypass-machine-cpb |access-date=2019-11-21 |website=www.ebme.co.uk |language=en-GB |vauthors=Davies H}}</ref>
[[File:Speed_vs_time_for_objects_with_drag.png|thumb|An object falling through viscous medium accelerates quickly towards its terminal speed, approaching gradually as the speed gets nearer to the terminal speed. Whether the object experiences turbulent or laminar drag changes the characteristic shape of the graph with turbulent flow resulting in a constant acceleration for a larger fraction of its accelerating time.]]
The [[velocity]] as a function of time for an object falling through a non-dense medium, and released at zero relative-velocity ''v''&nbsp;=&nbsp;0 at time ''t''&nbsp;=&nbsp;0, is roughly given by a function involving a [[hyperbolic tangent]] (tanh):<math display="block"> v(t) = \sqrt{ \frac{2mg}{\rho A C_d} } \tanh \left(t \sqrt{\frac{g \rho C_d A}{2 m}} \right). \,</math>The hyperbolic tangent has a [[Limit of a function|limit]] value of one, for large time ''t''. In other words, velocity [[asymptotically]] approaches a maximum value called the [[terminal velocity]] ''v<sub>t</sub>'':<math display="block">v_{t} = \sqrt{ \frac{2mg}{\rho A C_d} }. \,</math>For an object falling and released at relative-velocity ''v''&nbsp;=&nbsp;v<sub>i</sub> at time ''t''&nbsp;=&nbsp;0, with ''v<sub>i</sub>'' < ''v<sub>t</sub>'', is also defined in terms of the hyperbolic tangent function:<math display="block">v(t) = v_t \tanh \left( t \frac{ g }{ v_t } + \operatorname{arctanh}\left( \frac{ v_i}{ v_t} \right) \right). \,</math>For v<sub>i</sub> > v<sub>t</sub>, the velocity function is defined in terms of the [[hyperbolic cotangent]] function:<math display="block">v(t) = v_t \coth \left( t \frac{ g }{ v_t } + \coth^{-1}\left( \frac{ v_i}{ v_t} \right) \right). \,</math>The hyperbolic cotangent has also a [[Limit of a function|limit]] value of one, for large time ''t''. Velocity [[asymptotically]] tends to the [[terminal velocity]] ''v<sub>t</sub>'', strictly from above ''v<sub>t</sub>''.


For ''v<sub>i</sub>'' = ''v<sub>t</sub>'', the velocity is constant:<math display="block">v(t) = v_t. </math>Actually, these functions are defined by the solution of the following [[differential equation]]:<math display="block">g - \frac{\rho A C_d}{2m} v^2 = \frac{dv}{dt}. \,</math>Or, more generically (where ''F''(''v'') are the forces acting on the object beyond drag):<math display="block">\frac{1}{m}\sum F(v) - \frac{\rho A C_d}{2m} v^2 = \frac{dv}{dt}. \,</math>For a potato-shaped object of average diameter ''d'' and of density ''ρ<sub>obj</sub>'', terminal velocity is about<math display="block">v_{t} = \sqrt{ gd \frac{ \rho_{obj} }{\rho} }. \,</math>For objects of water-like density (raindrops, hail, live objects—mammals, birds, insects, etc.) falling in air near Earth's surface at sea level, the terminal velocity is roughly equal to<math display="block">v_{t} = 90 \sqrt{ d }, \,</math>with ''d'' in metre and ''v<sub>t</sub>'' in m/s. For example, for a human body (<math> d </math> ≈0.6 m) <math> v_t </math> ≈70&nbsp;m/s, for a small animal like a cat (<math> d </math> ≈0.2 m) <math> v_t </math> ≈40&nbsp;m/s, for a small bird (<math> d </math> ≈0.05 m) <math> v_t </math> ≈20&nbsp;m/s, for an insect (<math> d </math> ≈0.01 m) <math> v_t </math> ≈9&nbsp;m/s, and so on. Terminal velocity for very small objects (pollen, etc.) at low Reynolds numbers is determined by Stokes law.
=== Pumps ===


Terminal velocity is higher for larger creatures, and thus potentially more deadly. A creature such as a mouse falling at its terminal velocity is much more likely to survive impact with the ground than a human falling at its terminal velocity. A small animal such as a [[Cricket (insect)|cricket]] impacting at its terminal velocity will probably be unharmed. This, combined with the relative ratio of limb cross-sectional area vs. body mass (commonly referred to as the [[square–cube law]]), explains why very small animals can fall from a large height and not be harmed.<ref>Haldane, J.B.S., [http://irl.cs.ucla.edu/papers/right-size.html "On Being the Right Size"] {{Webarchive|url=https://web.archive.org/web/20110822151104/http://irl.cs.ucla.edu/papers/right-size.html|date=2011-08-22}}</ref>
==== Centrifugal pump ====
Many CPB circuits now employ a [[centrifugal pump]] for the maintenance and control of blood flow during CPB. By altering the speed of revolution (RPM) of the pump head, blood flow is produced by [[centrifugal force]]. This type of pumping action is considered to be superior to the action of the roller pump by many because it is thought to prevent overpressurization, clamping or kinking of lines, and produce less damage to blood products ([[hemolysis]], etc.).<ref name=":0" />


== Very low Reynolds numbers: Stokes' drag ==
==== Roller pump ====
[[File:Inclinedthrow.gif|thumb|[[Trajectory|Trajectories]] of three objects thrown at the same angle (70°). The black object does not experience any form of drag and moves along a parabola. The blue object experiences [[Stokes' law|Stokes' drag]], and the green object [[Newtonian fluid|Newton drag]].]]
The pump console usually comprises several rotating motor-driven pumps that [[Peristalsis|peristaltically]] "massage" tubing. This action gently propels the blood through the tubing. This is commonly referred to as a roller pump, or [[peristaltic pump]]. The pumps are more affordable than their centrifugal counterparts, but are susceptible to overpressurization if the lines become clamped or kinked.<ref name=":0" /> They are also more likely to cause a massive air embolism and require constant, close supervision by the perfusionist.<ref name=":3" />
{{main|Stokes' law}}


The equation for '''viscous resistance''' or '''linear drag''' is appropriate for objects or particles moving through a fluid at relatively slow speeds where there is no turbulence (i.e. low [[Reynolds number]], <math>R_e < 1</math>).<ref>[http://www.ac.wwu.edu/~vawter/PhysicsNet/Topics/Dynamics/Forces/DragForce.html Drag Force<!-- Bot generated title -->] {{webarchive|url=https://web.archive.org/web/20080414225930/http://www.ac.wwu.edu/~vawter/PhysicsNet/Topics/Dynamics/Forces/DragForce.html|date=April 14, 2008}}</ref> Purely laminar flow only exists up to Re = 0.1 under this definition. In this case, the force of drag is approximately proportional to velocity. The equation for viscous resistance is:<ref>[http://hyperphysics.phy-astr.gsu.edu/hbase/airfri.html Air friction], from Department of Physics and Astronomy, Georgia State University</ref><math display="block">\mathbf{F}_d = - b \mathbf{v} \,</math>where:
=== Oxygenator ===
The [[oxygenator]] is designed to add [[oxygen]] to infused [[blood]] and remove some of the [[carbon dioxide]] from the [[venous blood]]. Cardiac surgery was made possible by CPB using [[Bubble oxygenator|bubble oxygenators]], but [[Membrane oxygenator|membrane oxygenators]] have supplanted bubble oxygenators since the 1980s. The main reasons for this are that [[Membrane oxygenator|membrane oxygenators]] tend to generate far fewer micro-bubbles, referred to as gaseous microemboli, which is generally considered harmful to the patient and reduce damage to blood cells,<ref>{{cite journal |vauthors=Pearson DT, Holden M, Poslad S, Murray A, Waterhouse P |year=1984 |title=A clinical comparison of the gas transfer characteristics and gaseous microemboli production of one membrane and five bubble oxygenators: haemocompatibility |journal=Perfusion |volume=1 |issue=1 |pages=81–98 |doi=10.1177/026765918600100103 |s2cid=71419747}}</ref> compared to [[Bubble oxygenator|bubble oxygenators]]. More recently, the use of hollow-fiber oxygenators has become more widespread. These derivatives of membrane oxygenators further reduce the occurrence of microemboli by reducing the direct air-blood interface while simultaneously providing adequate gas exchange.<ref name=":0" />


* <math> b </math> is a constant that depends on both the material properties of the object and fluid, as well as the geometry of the object; and
Another type of oxygenator gaining favour recently is the heparin-coated blood oxygenator which is believed to produce less systemic inflammation and decrease the propensity for blood to clot in the CPB circuit.{{Citation needed|date=January 2020}}
* <math> \mathbf{v} </math> is the velocity of the object.


When an object falls from rest, its velocity will be<math display="block">v(t) = \frac{(\rho-\rho_0)\,V\,g}{b}\left(1-e^{-b\,t/m}\right)</math>where:
=== Heat exchangers ===
Because hypothermia is frequently used in CPB to reduce metabolic demands (including that of the heart), heat exchangers are implemented to warm and cool blood within the circuit. The heating and cooling is accomplished by passing the line through a warm or ice water bath. A separate heat exchanger is required for the cardioplegia line.<ref name=":3" />


* <math> \rho </math> is the density of the object,
=== Cannulae ===
* <math> \rho_0 </math> is density of the fluid,
Multiple [[Cannula|cannulae]] are sewn into the patient's body in a variety of locations, depending on the type of surgery. A venous cannula removes oxygen depleted venous blood from a patient's body. An arterial cannula infuses oxygen-rich blood into the arterial system. The main determinants of cannula size selection is determined by the patient's size and weight, anticipated flow rate, and the size of the vessel being cannulated.<ref name=":3" /> A [[cardioplegia]] cannula delivers a cardioplegia solution to cause the heart to stop beating.
* <math> V </math> is the volume of the object,
* <math> g </math> is the acceleration due to gravity (i.e., 9.8&nbsp;m/s<math>^2</math>), and
* <math> m </math> is mass of the object.


The velocity asymptotically approaches the terminal velocity <math> v_t = \frac{(\rho-\rho_0)Vg}{b}</math>. For a given <math> b </math>, denser objects fall more quickly.
Some commonly used cannulation sites:
{| class="wikitable"
!Venous
!Arterial
!Cardioplegia
|-
|[[Right atrium]]
|Proximal [[aorta]], distal to the [[Aortic cross-clamp|cross-clamp]]
|Proximal [[aorta]], proximal to the [[Aortic cross-clamp|cross-clamp]]
|-
|[[Vena cavae]]
|[[Femoral artery]]
|[[Coronary sinus]] (retrograde delivery)
|-
|[[Femoral vein]]
|[[Axillary artery]]
|Coronary ostia
|-
|
|Distal [[aorta]]
|Bypass grafts (during [[CABG]])
|-
|
|Apex of the [[heart]]
|
|-
|}


For the special case of small spherical objects moving slowly through a [[Viscosity|viscous]] fluid (and thus at small Reynolds number), [[George Gabriel Stokes]] derived an expression for the drag constant:<math display="block">b = 6 \pi \eta r\,</math>where <math> r </math> is the [[Stokes radius]] of the particle, and <math> \eta </math> is the [[fluid]] viscosity.
=== Cardioplegia ===
{{main|Cardioplegia}}


The resulting expression for the drag is known as [[Stokes' drag]]:<ref>{{Cite book |last1=Collinson |first1=Chris |title=Particle Mechanics |last2=Roper |first2=Tom |publisher=Butterworth-Heinemann |year=1995 |isbn=9780080928593 |page=30}}</ref><math display="block">\mathbf{F}_d = -6 \pi \eta r\, \mathbf{v}.</math>For example, consider a small sphere with radius <math> r </math> = 0.5 micrometre (diameter = 1.0&nbsp;µm) moving through water at a velocity <math> v </math> of 10&nbsp;µm/s. Using 10<sup>−3</sup> Pa·s as the [[dynamic viscosity]] of water in SI units, we find a drag force of 0.09 pN. This is about the drag force that a bacterium experiences as it swims through water.
Cardioplegia is a fluid solution used to protect the heart during CPB. It is delivered via a cannula to the opening of the coronary arteries (usually by way of the aortic root) and/or to the cardiac veins (by way of the coronary sinus).<ref name=":0" /> These delivery methods are referred to antegrade and retrograde, respectively. Cardioplegia solution protects the heart by arresting (i.e. stopping) the heart, thereby decreasing its metabolic demand. There are multiple types of cardioplegia solutions, but most work by inhibiting [[Sodium channel|fast sodium currents]] in the heart, thereby preventing conduction of the [[action potential]]. Other types of solutions act by inhibiting calcium's actions on [[Myocyte|myocytes]].<ref name=":2" />


The drag coefficient of a sphere can be determined for the general case of a laminar flow with Reynolds numbers less than <math>12 \cdot 10^5</math> using the following formula:<ref>{{Cite web |last=tec-science |date=2020-05-31 |title=Drag coefficient (friction and pressure drag) |url=https://www.tec-science.com/mechanics/gases-and-liquids/drag-coefficient-friction-and-pressure-drag/ |access-date=2020-06-25 |website=tec-science |language=en-US}}</ref><math display="block">C_D = \frac{24}{Re} +\frac{4}{\sqrt{Re}}+0.4 ~\text{;}~~~~~Re<2\cdot 10^5</math>For Reynolds numbers less than 1, Stokes' law applies and the drag coefficient approaches <math>\frac{24}{Re}</math>!
== Uses ==
[[File:Blausen_0468_Heart-Lung_Machine.png|thumb|300x300px|Illustration of one typical way that a heart-lung machine may be connected to the veins and arteries near the heart. The three implements on the left represent (''from top to bottom'') the pump, the oxygenator, and the reservoir.]]
CPB is commonly used in operations or surgical procedures involving the heart. The technique allows the surgical team to oxygenate and circulate the patient's blood, thus allowing the surgeon to operate safely on the heart.<ref name=":3" /> In many operations, such as [[Coronary artery bypass surgery|coronary artery bypass grafting]] (CABG), the heart is [[Cardioplegia|arrested]], due to the of the difficulty of operating on a beating heart.


== Aerodynamics ==
Operations requiring the opening of the chambers of the heart, for example [[mitral valve repair]] or [[Mitral valve replacement|replacement]], requires the use of CPB. This is to avoid engulfing air systemically, and to provide a bloodless field to increase visibility for the surgeon. The machine pumps the blood and, using an oxygenator, allows red blood cells to pick up oxygen, as well as allowing carbon dioxide levels to decrease.<ref name=":2">{{Cite book |title=TSRA Primer of Cardiothoracic Surgery |vauthors=Youssef SJ, Williams JA |publisher=TSRA/TSDA |year=2013 |isbn=978-0-9894023-0-9 |location=Chicago, IL}}</ref> This mimics the function of the heart and the lungs, respectively.
In [[aerodynamics]], '''aerodynamic drag''' (also known as '''air resistance''') is the fluid drag force that acts on any moving solid body in the direction of the air [[freestream]] flow.<ref>Anderson, John D. Jr., ''Introduction to Flight''</ref> From the body's perspective (near-field approach), the drag results from forces due to pressure distributions over the body surface, symbolized <math>D_{pr}</math>, and forces due to skin friction, which is a result of viscosity, denoted <math>D_{f}</math>. Alternatively, calculated from the flowfield perspective (far-field approach), the drag force results from three natural phenomena: [[Shock wave|shock waves]], vortex sheet, and [[viscosity]].


=== Hypothermia ===
=== ===
The [[pressure]] distribution acting on a body's surface exerts normal forces on the body. Those forces can be summed and the component of that force that acts downstream represents the drag force, <math>D_{pr}</math>, due to pressure distribution acting on the body. The nature of these normal forces combines shock wave effects, vortex system generation effects, and wake viscous mechanisms.
CPB can be used for the induction of total body [[Therapeutic hypothermia|hypothermia]], a state in which the body can be maintained for up to 45 minutes without [[perfusion]] (blood flow).<ref name=":3" /> If blood flow is stopped at normal [[body temperature]], permanent [[brain damage]] can occur in three to four minutes – death may follow. Similarly, CPB can be used to rewarm individuals who have [[hypothermia]].<ref>{{cite journal |vauthors=McCullough L, Arora S |date=December 2004 |title=Diagnosis and treatment of hypothermia |journal=American Family Physician |volume=70 |issue=12 |pages=2325–2332 |pmid=15617296}}</ref> This rewarming method of using CPB is successful if the core temperature of the patient is above 16&nbsp;°C.<ref name="Lich_2004">{{cite book |title=The Manual of Clinical Perfusion |vauthors=Lich B, Brown M |publisher=perfusion.com |year=2004 |isbn=978-0-9753396-0-2 |edition=2nd |location=Fort Myers, Florida}}</ref>{{rp|117}}


The [[viscosity]] of the fluid has a major effect on drag. In the absence of viscosity, the pressure forces acting to retard the vehicle are canceled by a pressure force further aft that acts to push the vehicle forward; this is called pressure recovery and the result is that the drag is zero. That is to say, the work the body does on the airflow is reversible and is recovered as there are no frictional effects to convert the flow energy into heat. Pressure recovery acts even in the case of viscous flow. Viscosity, however results in pressure drag and it is the dominant component of drag in the case of vehicles with regions of separated flow, in which the pressure recovery is fairly ineffective.
=== Cooled Blood ===
The blood is cooled during CPB and is returned to the body. The cooled blood slows the body's basal metabolic rate, decreasing its demand for oxygen. Cooled blood usually has a higher viscosity, but the various crystalloid or colloidal solutions that are used to prime the bypass tubing serve to dilute the blood. Maintaining appropriate blood pressure for organs is a challenge, but it is monitored carefully during the procedure. Hypothermia is also maintained (if necessary), and the body temperature is usually kept at 28&nbsp;°C to 32&nbsp;°C (82.4–89.6&nbsp;°F).


The friction drag force, which is a tangential force on the aircraft surface, depends substantially on [[boundary layer]] configuration and viscosity. The net friction drag, <math>D_f</math>, is calculated as the downstream projection of the viscous forces evaluated over the body's surface.
=== Extracorporeal Membrane Oxygenation (ECMO) ===
[[Extracorporeal membrane oxygenation]] (ECMO) is a simplified version of the [[heart lung machine]] that includes a [[centrifugal pump]] and an oxygenator to temporarily take over the function of heart and/or the lungs. ECMO is useful for: Post-cardiac surgery patients with cardiac or pulmonary dysfunction, patients with acute pulmonary failure, massive [[pulmonary embolisms]], lung trauma from infections, and a range of other problems that impair cardiac or pulmonary function.


The sum of friction drag and pressure (form) drag is called viscous drag. This drag component is due to viscosity. In a thermodynamic perspective, viscous effects represent irreversible phenomena and, therefore, they create entropy. The calculated viscous drag <math>D_v</math> use entropy changes to accurately predict the drag force.
ECMO gives the heart and/or lungs time to repair and recover, but is only a temporary solution. Patients with terminal conditions, cancer, severe nervous system damage, uncontrolled [[sepsis]], and other conditions may not be candidates for ECMO.<ref name="Lich_2004" />{{rp|141}}


When the airplane produces lift, another drag component results. [[Lift-induced drag|Induced drag]], symbolized <math>D_i</math>, is due to a modification of the pressure distribution due to the trailing vortex system that accompanies the lift production. An alternative perspective on lift and drag is gained from considering the change of momentum of the airflow. The wing intercepts the airflow and forces the flow to move downward. This results in an equal and opposite force acting upward on the wing which is the lift force. The change of momentum of the airflow downward results in a reduction of the rearward momentum of the flow which is the result of a force acting forward on the airflow and applied by the wing to the air flow; an equal but opposite force acts on the wing rearward which is the induced drag. Another drag component, namely [[wave drag]], <math>D_w</math>, results from shock waves in transonic and supersonic flight speeds. The shock waves induce changes in the boundary layer and pressure distribution over the body surface.
=== Surgical procedures in which cardiopulmonary bypass is used ===


In summary, there are three ways of categorising drag.<ref name="Gowree">{{cite thesis |last1=Gowree |first1=Erwin Ricky |title=Influence of Attachment Line Flow on Form Drag |date=20 May 2014 |url=https://openaccess.city.ac.uk/id/eprint/12239/ |access-date=22 March 2022 |type=doctoral}}</ref>{{rp|p=19}}
* [[Coronary artery bypass surgery]]<ref>{{cite book |last1=Al-Atassi |first1=Talal |title=Sabiston and Spencer Surgery of the Chest |last2=Toeg |first2=Hadi D. |last3=Chan |first3=Vincent |last4=Ruel |first4=Marc |year=2016 |isbn=978-0-323-24126-7 |editor1=Frank Sellke |page=1553–1554 |chapter=Coronary Artery Bypass Grafting |editor2=Pedro J. del Nido |editor2-link=Pedro J. del Nido}}</ref>
* Cardiac valve repair and/or replacement ([[aortic valve]], [[mitral valve]], [[tricuspid valve]], [[pulmonic valve]])
* Repair of large [[Septum|septal]] defects ([[atrial septal defect]], [[ventricular septal defect]], [[atrioventricular septal defect]])
* Repair and/or palliation of [[Congenital heart defect|congenital heart defects]] ([[Tetralogy of Fallot]], [[transposition of the great vessels]])
* Transplantation ([[heart transplantation]], [[lung transplantation]], [[heart–lung transplantation]], [[liver transplantation]])
* Repair of some large [[aneurysms]] ([[Aortic aneurysm|aortic aneurysms]], [[Cerebral aneurysm|cerebral aneurysms]])
* [[Pulmonary thromboendarterectomy]]<ref name="Madani2016">{{Cite book |last=Madani |first=Michael M. |title=Pulmonary Circulation: Diseases and Their Treatment, Fourth Edition |publisher=CRC Press |year=2016 |isbn=978-1-4987-1991-9 |editor-last=Peacock |editor-first=Andrew J. |pages=541 |language=en |chapter=50. Pulmonary Thromboendarterectomy |editor-last2=Naeije |editor-first2=Robert |editor-last3=Rubin |editor-first3=Lewis J. |chapter-url=https://books.google.com/books?id=pgzYCwAAQBAJ&q=Pulmonary+thromboendarterectomy+pte+pea&pg=PA541}}</ref>
* [[Pulmonary thrombectomy]]<ref>{{cite journal |vauthors=Casazza F, Roncon L, Greco F |date=Oct 2005 |title=Pulmonary embolism: treatment of the acute episode |journal=Ital Heart J. |volume=6 |issue=10 |pages=818–23 |pmid=16270473}}</ref>
* Isolated Limb perfusion<ref name="Lich_2004" />{{rp|117}}


# Pressure drag and friction drag
== Contraindications and Special Considerations ==
# Profile drag and induced drag
There are no absolute contraindications to cardiopulmonary bypass.<ref>{{Citation |title=Cardiopulmonary Bypass |vauthors=Ismail A, Miskolczi SY |date=2019 |work=StatPearls |url=http://www.ncbi.nlm.nih.gov/books/NBK482190/ |access-date=2020-01-21 |publisher=StatPearls Publishing |pmid=29489210}}</ref> However, there are several factors that must be considered by the care team when planning for an operation.
# Vortex drag, wave drag and wake drag


=== HIT and HITT ===
=== ===
The idea that a moving body passing through air or another fluid encounters resistance had been known since the time of [[Aristotle]]. According to [[Mervyn O'Gorman]], this was named "drag" by [[Archibald Reith Low]].<ref>https://archive.org/details/Flight_International_Magazine_1913-02-01-pdf/page/n19/mode/2up Flight, 1913, p. 126</ref> [[Louis Charles Breguet]]'s paper of 1922 began efforts to reduce drag by streamlining.<ref name="Anderson">{{cite book |last=Anderson |first=John David |title=''A History of Aerodynamics: And Its Impact On Flying Machines'' |publisher=University of Cambridge |year=1929}}</ref> Breguet went on to put his ideas into practice by designing several record-breaking aircraft in the 1920s and 1930s. [[Ludwig Prandtl]]'s boundary layer theory in the 1920s provided the impetus to minimise skin friction. A further major call for streamlining was made by Sir [[Melvill Jones]] who provided the theoretical concepts to demonstrate emphatically the importance of streamlining in [[aircraft]] design.<ref name="Cambridge">{{cite web |title=University of Cambridge Engineering Department |url=http://www-g.eng.cam.ac.uk/125/1925-1950/melvill2.html |access-date=28 Jan 2014}}</ref><ref name="Biography">{{cite book |last=Sir Morien Morgan |first=Sir Arnold Hall |title=''Biographical Memoirs of Fellows of the Royal Society'' ''Bennett Melvill Jones. 28 January 1887 -- 31 October 1975'' |date=November 1977 |publisher=The Royal Society |volume=23 |pages=252–282}}</ref><ref name="ODNB">{{cite book |last=Mair |first=W.A. |title=''Oxford Dictionary of National Biography'' |year=1976}}</ref> In 1929 his paper ‘The Streamline Airplane’ presented to the [[Royal Aeronautical Society]] was seminal. He proposed an ideal aircraft that would have minimal drag which led to the concepts of a 'clean' monoplane and retractable [[Landing gear|undercarriage]]. The aspect of Jones's paper that most shocked the designers of the time was his plot of the horse power required versus velocity, for an actual and an ideal plane. By looking at a data point for a given aircraft and extrapolating it horizontally to the ideal curve, the velocity gain for the same power can be seen. When Jones finished his presentation, a member of the audience described the results as being of the same level of importance as the [[Carnot cycle]] in thermodynamics.<ref name="Anderson" /><ref name="Cambridge" />
[[Heparin-induced thrombocytopenia]] (HIT) and [[heparin-induced thrombocytopenia and thrombosis]] (HITT) are potentially life-threatening conditions associated with the administration of heparin. In both of these conditions, [[Antibody|antibodies]] against heparin are formed which causes [[Coagulation|platelet activation]] and the formation of [[Thrombus|blood clots]]. Because heparin is typically used in CPB, patients who are known to have the antibodies responsible for heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis require alternative forms of anticoagulation. [[Bivalirudin]] is the most studied heparin-alternative in people with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis requiring CPB.<ref>{{cite journal |vauthors=Shore-Lesserson L, Baker RA, Ferraris VA, Greilich PE, Fitzgerald D, Roman P, Hammon JW |date=February 2018 |title=The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines-Anticoagulation During Cardiopulmonary Bypass |journal=The Annals of Thoracic Surgery |volume=105 |issue=2 |pages=650–662 |doi=10.1016/j.athoracsur.2017.09.061 |pmid=29362176 |doi-access=free}}</ref>A small percentage of patients, such as those with an [[antithrombin III deficiency]], may exhibit resistance to heparin. In these cases, patients may need additional heparin, fresh frozen plasma, or other blood products (recombinant anti-thrombin III) to achieve adequate anticoagulation.<ref>{{cite journal |vauthors=Finley A, Greenberg C |date=June 2013 |title=Review article: heparin sensitivity and resistance: management during cardiopulmonary bypass |journal=Anesthesia and Analgesia |volume=116 |issue=6 |pages=1210–1222 |doi=10.1213/ANE.0b013e31827e4e62 |pmid=23408671 |s2cid=22500786 |doi-access=free}}</ref>


=== Lift-induced drag and parasitic drag ===
=== PLSVC ===
A [[persistent left superior vena cava]] (PLSVC) is a thoracic system variation in which the left-sided vena cava fails to involute during normal development. It is the most common variation of the thoracic venous system, occurring in approximately 0.3% of the population.<ref>{{cite journal |display-authors=6 |vauthors=Berg C, Knüppel M, Geipel A, Kohl T, Krapp M, Knöpfle G, Germer U, Hansmann M, Gembruch U |date=March 2006 |title=Prenatal diagnosis of persistent left superior vena cava and its associated congenital anomalies |journal=Ultrasound in Obstetrics & Gynecology |volume=27 |issue=3 |pages=274–280 |doi=10.1002/uog.2704 |pmid=16456841 |s2cid=26364072 |doi-access=free}}</ref> The abnormality is often detected on pre-operative imaging studies, but may also be discovered intra-operatively. A persistent left superior vena cava may make it difficult to achieve proper venous drainage or deliver of retrograde [[cardioplegia]]. Management of a persistent left superior vena cava during CPB depends on factors such as the size and drainage site of the vena cava variation.<ref name=":3" />


==== Lift-induced drag ====
== Risks and Complications ==
{{main|Lift-induced drag}}
{| class="wikitable"
|+Potential complications of cardiopulmonary bypass
!Complication
!Incidence
(events/1000)
!Death or serious
injury (%)
|-
|[[Protamine sulfate|Protamine reaction]]<ref name=":3" />
|1.3
|10.5
|-
|[[Thrombosis]]<ref name=":3" />
|0.3–0.4
|2.6–5.2
|-
|[[Aortic dissection]]<ref name=":3" />
|0.4–0.8
|14.3–33.1
|-
|[[Gas embolism]]
|0.2–1.3
|0.2–8.7
|-
|Massive systemic gas embolism<ref name=":3" />
|0.03–0.07
|50–52
|-
|Dislodging of cannula (causing massive bleeding)<ref name=":3" />
|0.2–1.6
|4.2–7.1
|-
|[[Acute respiratory distress syndrome]]<ref name=":3" />
|–
|–
|-
|[[Arrhythmia|Arrythmias]]<ref name=":3" />
|–
|–
|-
|[[Capillary leak syndrome]]<ref name=":1" />
|–
|–
|-
|[[Hemolysis]]<ref name=":1" />
|–
|–
|-
|[[Postperfusion syndrome]] ("pumphead")<ref name=":1" />
|–
|–
|}
CPB is not benign, but there are a number of associated problems. As a result, CPB is only used during several hours of a cardiac surgery. CPB is known to activate the coagulation cascade and stimulate inflammatory mediators, leading to hemolysis and coagulopathies. This problem worsens as complement proteins build on the membrane oxygenators.<ref name=":4">{{Cite book |title=Tsra review of cardiothoracic surgery. |vauthors=Lapar DJ |date=2016 |publisher=Createspace |isbn=978-1-5232-1716-8 |location=[Place of publication not identified] |oclc=953497320}}</ref> For this reason, most oxygenators come with a manufacturer's recommendation that they are only used for a maximum of six hours. Although these machines can sometimes be used for up to ten hours (with care), they must ensure they do not clot off and stop working. For longer periods, an [[Extracorporeal membrane oxygenation|ECMO]] is used.


'''Lift-induced drag''' (also called '''induced drag''') is drag which occurs as the result of the creation of [[Lift (force)|lift]] on a three-dimensional [[lifting body]], such as the [[wing]] or [[Propeller (aeronautics)|propeller]] of an airplane. Induced drag consists primarily of two components: drag due to the creation of trailing vortices ('''vortex drag'''); and the presence of additional viscous drag ('''lift-induced viscous drag''') that is not present when lift is zero. The trailing vortices in the flow-field, present in the wake of a lifting body, derive from the turbulent mixing of air from above and below the body which flows in slightly different directions as a consequence of creation of [[Lift (force)|lift]].
The most common complication associated with CPB is a [[Protamine sulfate|protamine]] reaction during anticoagulation reversal.<ref name=":3" /> There are three types of protamine reactions, and each may cause life-threatening [[hypotension]] (type I), [[anaphylaxis]] (type II), or [[pulmonary hypertension]] (type III).<ref>{{cite journal |vauthors=Nybo M, Madsen JS |date=August 2008 |title=Serious anaphylactic reactions due to protamine sulfate: a systematic literature review |journal=Basic & Clinical Pharmacology & Toxicology |volume=103 |issue=2 |pages=192–196 |doi=10.1111/j.1742-7843.2008.00274.x |pmid=18816305 |doi-access=free}}</ref><ref name=":4" /> Patients with prior exposure to protamine, such as those who have had a previous [[vasectomy]] (protamine is contained in sperm) or [[Diabetes|diabetics]] (protamine is contained in [[NPH insulin|neutral protamine hagedorn]] (NPH) insulin formulations), are at an increased risk of type II protamine reactions due to cross-sensitivity.<ref name=":4" /> Because protamine is a fast-acting drug, it is typically given slowly to allow for monitoring of possible reactions.<ref name=":1" /> The first step in management of a protamine reaction is to immediately stop the protamine infusion. [[Corticosteroid|Corticosteroids]] are used for all types of protamine reactions. [[Chlorphenamine]] is used for type II (anaphylactic) reactions. For type III reactions, heparin is redosed and the patient may need to go back on bypass.<ref name=":4" />


With other parameters remaining the same, as the [[Lift (force)|lift]] generated by a body increases, so does the lift-induced drag. This means that as the wing's [[angle of attack]] increases (up to a maximum called the stalling angle), the [[lift coefficient]] also increases, and so too does the lift-induced drag. At the onset of [[Stall (flight)|stall]], lift is abruptly decreased, as is lift-induced drag, but viscous pressure drag, a component of parasite drag, increases due to the formation of turbulent unattached flow in the wake behind the body.
CPB may contribute to immediate cognitive decline. The heart-lung blood circulation system and the connection surgery itself release a variety of debris into the bloodstream, including bits of blood cells, tubing, and plaque. For example, when surgeons clamp and connect the aorta to tubing, resulting emboli may block blood flow and cause mini strokes. Other heart surgery factors related to mental damage may be events of hypoxia, high or low body temperature, abnormal blood pressure, irregular heart rhythms, and fever after surgery.<ref>{{cite web |date=9 January 2009 |title=Pumphead: Does the heart-lung machine have a dark side? |url=http://www.scientificamerican.com/article.cfm?id=pumphead-heart-lung-machine |work=Scientific American |vauthors=Stutz B}}</ref>


==== Parasitic drag ====
{{clear}}
{{main|Parasitic drag}}

'''Parasitic drag''', or profile drag, is drag caused by moving a solid object through a fluid. Parasitic drag is made up of multiple components including viscous pressure drag ('''form drag'''), and drag due to surface roughness ('''skin friction drag'''). Additionally, the presence of multiple bodies in relative proximity may incur so called '''interference drag''', which is sometimes described as a component of parasitic drag.

In aviation, induced drag tends to be greater at lower speeds because a high [[angle of attack]] is required to maintain lift, creating more drag. However, as speed increases the angle of attack can be reduced and the induced drag decreases. Parasitic drag, however, increases because the fluid is flowing more quickly around protruding objects increasing friction or drag. At even higher speeds ([[transonic]]), [[wave drag]] enters the picture. Each of these forms of drag changes in proportion to the others based on speed. The combined overall drag curve therefore shows a minimum at some airspeed - an aircraft flying at this speed will be at or close to its optimal efficiency. Pilots will use this speed to maximize [[Endurance (aircraft)|endurance]] (minimum fuel consumption), or maximize [[Glide ratio|gliding range]] in the event of an engine failure.

=== Power curve in aviation ===
[[File:Drag_curves_for_aircraft_in_flight.svg|thumb|The ''power curve'': parasitic drag and lift-induced drag ''vs.'' airspeed]]
{{main|Drag curve}}

The interaction of parasitic and induced drag ''vs.'' airspeed can be plotted as a characteristic curve, illustrated here. In aviation, this is often referred to as the ''power curve'', and is important to pilots because it shows that, below a certain airspeed, maintaining airspeed counterintuitively requires ''more'' thrust as speed decreases, rather than less. The consequences of being "behind the curve" in flight are important and are taught as part of pilot training. At the subsonic airspeeds where the "U" shape of this curve is significant, wave drag has not yet become a factor, and so it is not shown in the curve.

=== Wave drag in transonic and supersonic flow ===
[[File:Qualitive_variation_of_cd_with_mach_number.png|thumb|Qualitative variation in Cd factor with Mach number for aircraft]]
{{main|Wave drag}}

'''Wave drag''' (also called '''compressibility drag''') is drag that is created when a body moves in a compressible fluid and at speeds that are close to the speed of sound in that fluid. In [[aerodynamics]], wave drag consists of multiple components depending on the speed regime of the flight.

In transonic flight (Mach numbers greater than about 0.8 and less than about 1.4), wave drag is the result of the formation of shockwaves in the fluid, formed when local areas of supersonic (Mach number greater than 1.0) flow are created. In practice, supersonic flow occurs on bodies traveling well below the speed of sound, as the local speed of air increases as it accelerates over the body to speeds above Mach 1.0. However, full supersonic flow over the vehicle will not develop until well past Mach 1.0. Aircraft flying at transonic speed often incur wave drag through the normal course of operation. In transonic flight, wave drag is commonly referred to as '''transonic compressibility drag'''. Transonic compressibility drag increases significantly as the speed of flight increases towards Mach 1.0, dominating other forms of drag at those speeds.

In supersonic flight (Mach numbers greater than 1.0), '''wave drag''' is the result of shockwaves present in the fluid and attached to the body, typically '''oblique shockwaves''' formed at the leading and trailing edges of the body. In highly supersonic flows, or in bodies with turning angles sufficiently large, '''unattached shockwaves''', or '''bow waves''' will instead form. Additionally, local areas of transonic flow behind the initial shockwave may occur at lower supersonic speeds, and can lead to the development of additional, smaller shockwaves present on the surfaces of other lifting bodies, similar to those found in transonic flows. In supersonic flow regimes, '''wave drag''' is commonly separated into two components, '''supersonic lift-dependent wave drag''' and '''supersonic volume-dependent wave drag'''.

The closed form solution for the minimum wave drag of a body of revolution with a fixed length was found by Sears and Haack, and is known as the '''Sears-Haack Distribution'''. Similarly, for a fixed volume, the shape for minimum wave drag is the '''Von Karman Ogive'''.

The [[Busemann biplane]] theoretical concept is not subject to wave drag when operated at its design speed, but is incapable of generating lift in this condition.

== d'Alembert's paradox ==
{{main|d'Alembert's paradox}}

In 1752 [[Jean le Rond d'Alembert|d'Alembert]] proved that [[potential flow]], the 18th century state-of-the-art [[inviscid flow]] theory amenable to mathematical solutions, resulted in the prediction of zero drag. This was in contradiction with experimental evidence, and became known as d'Alembert's paradox. In the 19th century the [[Navier–Stokes equations]] for the description of [[Viscosity|viscous]] flow were developed by [[Adhémar Jean Claude Barré de Saint-Venant|Saint-Venant]], [[Claude-Louis Navier|Navier]] and [[George Gabriel Stokes|Stokes]]. Stokes derived the drag around a sphere at very low [[Reynolds number|Reynolds numbers]], the result of which is called [[Stokes' law]].<ref name="Batchelor">Batchelor (2000), pp. 337–343.</ref>

In the limit of high Reynolds numbers, the Navier–Stokes equations approach the inviscid [[Euler equations (fluid dynamics)|Euler equations]], of which the potential-flow solutions considered by d'Alembert are solutions. However, all experiments at high Reynolds numbers showed there is drag. Attempts to construct inviscid [[steady flow]] solutions to the Euler equations, other than the potential flow solutions, did not result in realistic results.<ref name="Batchelor" />

The notion of [[Boundary layer|boundary layers]]—introduced by [[Ludwig Prandtl|Prandtl]] in 1904, founded on both theory and experiments—explained the causes of drag at high Reynolds numbers. The boundary layer is the thin layer of fluid close to the object's boundary, where viscous effects remain important even when the viscosity is very small (or equivalently the Reynolds number is very large).<ref name="Batchelor" />

== See also ==
{{div col|colwidth=22em}}
* [[Added mass]]
* [[Aerodynamic force]]
* [[Angle of attack]]
* [[Atmospheric density]]
* [[Automobile drag coefficient]]
* [[Boundary layer]]
* [[Coandă effect]]
* [[Drag crisis]]
* [[Drag coefficient]]
* [[Drag equation]]
* [[Gravity drag]]
* [[Keulegan–Carpenter number]]
* [[Lift (force)]]
* [[Morison equation]]
* [[Nose cone design]]
* [[Parasitic drag]]
* [[Projectile motion#Trajectory of a projectile with air resistance]]
* [[Ram pressure]]
* [[Reynolds number]]
* [[Stall (fluid mechanics)]]
* [[Stokes' law]]
* [[Terminal velocity]]
* [[Wave drag]]
* [[Windage]]
{{div col end}}


== References ==
== References ==
<references group="" responsive="0"></references>
<references group="" responsive="0"></references>


* 'Improved Empirical Model for Base Drag Prediction on Missile Configurations, based on New Wind Tunnel Data', Frank G Moore et al. NASA Langley Center
== Further reading ==
* 'Computational Investigation of Base Drag Reduction for a Projectile at Different Flight Regimes', M A Suliman et al. Proceedings of 13th International Conference on Aerospace Sciences & Aviation Technology, ASAT- 13, May 26 – 28, 2009
{{refbegin}}
* 'Base Drag and Thick Trailing Edges', Sighard F. Hoerner, Air Materiel Command, in: Journal of the Aeronautical Sciences, Oct 1950, pp 622–628
* {{cite book |title=Cardiac Surgery in the Adult |vauthors=Hessel EA, Edmunds LH |publisher=McGraw-Hill |year=2003 |veditors=Cohn LH, Edmunds LH |location=New York |pages=317–38 |chapter=Extracorporeal Circulation: Perfusion Systems |access-date=2006-12-09 |chapter-url=http://cardiacsurgery.ctsnetbooks.org/cgi/content/full/2/2003/317 |archive-url=https://web.archive.org/web/20061210154850/http://cardiacsurgery.ctsnetbooks.org/cgi/content/full/2/2003/317# |archive-date=2006-12-10 |url-status=dead}}

{{refend}}
== Bibliography ==

* {{cite book |author=French, A. P. |title=Newtonian Mechanics (The M.I.T. Introductory Physics Series) |publisher=W. W. White & Company Inc., New York |year=1970 |isbn=978-0-393-09958-4 |edition=1st}}
* {{cite book |author=G. Falkovich |url=http://www.cambridge.org/gb/knowledge/isbn/item6173728/?site_locale=en_GB |title=Fluid Mechanics (A short course for physicists) |publisher=Cambridge University Press |year=2011 |isbn=978-1-107-00575-4 |ref=Falkovich}}
* {{cite book |author1=Serway, Raymond A. |url=https://archive.org/details/physicssciengv2p00serw |title=Physics for Scientists and Engineers |author2=Jewett, John W. |publisher=Brooks/Cole |year=2004 |isbn=978-0-534-40842-8 |edition=6th |url-access=registration}}
* {{cite book |author=Tipler, Paul |title=Physics for Scientists and Engineers: Mechanics, Oscillations and Waves, Thermodynamics |publisher=W. H. Freeman |year=2004 |isbn=978-0-7167-0809-4 |edition=5th}}
* {{cite book |last=Huntley |first=H. E. |title=Dimensional Analysis |publisher= |year=1967 |id=LOC 67-17978}}
* {{cite book |author=Batchelor, George |title=An introduction to fluid dynamics |publisher=[[Cambridge University Press]] |year=2000 |isbn=978-0-521-66396-0 |edition=2nd |series=Cambridge Mathematical Library |mr=1744638 |author-link=George Batchelor}}
* [[L. J. Clancy]] (1975), ''Aerodynamics'', Pitman Publishing Limited, London. {{ISBN|978-0-273-01120-0}}
* Anderson, John D. Jr. (2000); ''Introduction to Flight'', Fourth Edition, McGraw Hill Higher Education, Boston, Massachusetts, USA. 8th ed. 2015, {{ISBN|978-0078027673}}.


== External links ==
== External links ==
{{Commons category|Cardiopulmonary bypass}}


* [[arxiv:physics/0609156|Educational materials on air resistance]]
* [http://www.bestpracticeperfusion.org/ International Consortium For Evidence-Based Perfusion]
* [https://web.archive.org/web/20070812225237/http://craig.backfire.ca/pages/autos/drag Aerodynamic Drag] and its effect on the acceleration and top speed of a vehicle.
* [http://circuitsurfers.com/ CircuitSurfers: A Perfusion Blog about Cardiopulmonary Bypass]
* [http://www.apexgarage.com/tech/horsepower_calc.shtml Vehicle Aerodynamic Drag calculator] based on drag coefficient, frontal area and speed.
* [https://web.archive.org/web/20111101192126/http://mmcts.ctsnetjournals.org/cgi/collection/cardiopulmonary_bypass Multimedia Manual of Cardiothoracic Surgery. Cardiopulmonary bypass collection.]
* [http://howthingsfly.si.edu/ Smithsonian National Air and Space Museum's How Things Fly website]
* {{cite web |title=The Clarence Dennis Papers |url=http://profiles.nlm.nih.gov/ps/retrieve/Collection/CID/BX |work=Profiles in Science |publisher=U.S. National Library of Medicine}} credited with the first attempt at cardiopulmonary bypass surgery.
* [https://www.academia.edu/9931460/Effect_of_dimples_on_a_golf_ball_and_a_car Effect of dimples on a golf ball and a car]
{{Cardiac surgery}}{{Vascular procedures}}

{{Authority control}}
[[Category:Wikipedia Student Program]]
[[Category:Wikipedia Student Program]]

Revision as of 22:15, 15 February 2024

In fluid dynamics, drag, sometimes referred to as fluid resistance, is a force acting opposite to the relative motion of any object moving with respect to a surrounding fluid.[1] This can exist between two fluid layers (or surfaces), or between a fluid and a solid surface. Drag forces always tend to decrease fluid velocity relative to the solid object in the fluid's path.

Unlike other resistive forces, drag force depends on velocity.[2][3] Drag force is proportional to the velocity for low-speed flow and the squared velocity for high speed flow. This distinction between low and high speed flow is measured by the Reynolds number.

Examples

Examples of drag include the component of the net aerodynamic or hydrodynamic force, acting opposite to the direction of movement of a solid object such as cars (automobile drag coefficient), aircraft[3] and boat hulls. Moreover, acting in the same geographical direction of motion as the solid, as for sails attached to a down wind sail boat, or in intermediate directions on a sail depending on points of sail.[4][5][6] In the case of viscous drag of fluid in a pipe, drag force on the immobile pipe decreases fluid velocity relative to the pipe.[7][8]

In the physics of sports, the drag force is necessary to explain the motion of balls, javelins, arrows and frisbees and the performance of runners and swimmers.[9]

Types

Shape and flow Form

Drag

Skin

friction

≈0% ≈100%
≈10% ≈90%
≈90% ≈10%
≈100% ≈0%

Types of drag are generally divided into the following categories:

The effect of streamlining on the relative proportions of skin friction and form drag is shown for two different body sections, an airfoil, which is a streamlined body, and a cylinder, which is a bluff body. Also shown is a flat plate illustrating the effect that orientation has on the relative proportions of skin friction and pressure difference between front and back. A body is known as bluff (or blunt) if the source of drag is dominated by pressure forces and streamlined if the drag is dominated by viscous forces. Road vehicles are bluff bodies.[10] For aircraft, pressure and friction drag are included in the definition of parasitic drag. Parasite drag is often expressed in terms of a hypothetical (in so far as there is no edge spillage drag[11]) "equivalent parasite drag area" which is the area of a flat plate perpendicular to the flow. It is used for comparing the drag of different aircraft. For example, the Douglas DC-3 has an equivalent parasite area of 23.7 sq ft and the McDonnell Douglas DC-9, with 30 years of advancement in aircraft design, an area of 20.6 sq ft although it carried five times as many passengers.[12]

  • lift-induced drag appears with wings or a lifting body in aviation and with semi-planing or planing hulls for watercraft
  • wave drag (aerodynamics) is caused by the presence of shockwaves and first appears at subsonic aircraft speeds when local flow velocities become supersonic. The wave drag of the supersonic Concorde prototype aircraft was reduced at Mach 2 by 1.8% by applying the area rule which extended the rear fuselage 3.73m on the production aircraft.[13]
  • wave resistance (ship hydrodynamics) or wave drag occurs when a solid object is moving along a fluid boundary and making surface waves
  • boat-tail drag on an aircraft is caused by the angle with which the rear fuselage, or engine nacelle, narrows to the engine exhaust diameter.[14]

Drag Equation

Drag coefficient Cd for a sphere as a function of Reynolds number Re, as obtained from laboratory experiments. The dark line is for a sphere with a smooth surface, while the lighter line is for the case of a rough surface.

Drag depends on the properties of the fluid as well as the size, shape, and speed of the object. One way to express this concept is through the drag equation:Key:


The drag coefficient depends on the shape of the object and on the Reynolds numberKey:

  • is the equivalent diameter of the object. For a sphere, is the D of the sphere itself.
  • For a rectangular shape cross-section in the motion direction, , where a and b are the rectangle edges.
  • is the kinematic viscosity of the fluid (equal to the dynamic viscosity divided by the density ).

At low , is asymptotically proportional to . This means that the drag is linearly proportional to the speed, i.e. the drag force on a small sphere moving through a viscous fluid is given by the Stokes Law:At high , is more or less constant and drag will vary as the square of the speed. The graph to the right shows how varies with for the case of a sphere. Since the power needed to overcome the drag force is the product of the force times speed, the power needed to overcome drag will vary as the square of the speed at low Reynolds numbers and as the cube of the speed at high numbers.

It can be demonstrated that drag force can be expressed as a function of a dimensionless number, which is dimensionally identical to the Bejan number.[16] Consequently, drag force and drag coefficient can be a function of Bejan number. In fact, from the expression of drag force it has been obtained:and consequently allows expressing the drag coefficient as a function of Bejan number and the ratio between wet area and front area :[16]where is the Reynolds number related to fluid path length L.

At High Velocity

Explanation of drag by NASA.

As mentioned, the drag equation with a constant drag coefficient gives the force experienced by an object moving through a fluid at relatively large velocity (i.e. high Reynolds number, Re > ~1000). This is also called quadratic drag. The equation is attributed to Lord Rayleigh, who originally used L2 in place of A (L being some length).The derivation of this equation is presented at Drag equation § Derivation.

The reference area A is often orthographic projection of the object (frontal area)—on a plane perpendicular to the direction of motion—e.g. for objects with a simple shape, such as a sphere, this is the cross sectional area. Sometimes a body is a composite of different parts, each with a different reference areas, in which case a drag coefficient corresponding to each of those different areas must be determined.

In the case of a wing the reference areas are the same and the drag force is in the same ratio to the lift force as the ratio of drag coefficient to lift coefficient.[17] Therefore, the reference for a wing is often the lifting area ("wing area") rather than the frontal area.[18]

For an object with a smooth surface, and non-fixed separation points—like a sphere or circular cylinder—the drag coefficient may vary with Reynolds number Re, even up to very high values (Re of the order 107).[19] [20] For an object with well-defined fixed separation points, like a circular disk with its plane normal to the flow direction, the drag coefficient is constant for Re > 3,500.[20] Further the drag coefficient Cd is, in general, a function of the orientation of the flow with respect to the object (apart from symmetrical objects like a sphere).

Power

Under the assumption that the fluid is not moving relative to the currently used reference system, the power required to overcome the aerodynamic drag is given by:The power needed to push an object through a fluid increases as the cube of the velocity. A car cruising on a highway at 50 mph (80 km/h) may require only 10 horsepower (7.5 kW) to overcome aerodynamic drag, but that same car at 100 mph (160 km/h) requires 80 hp (60 kW).[21] With a doubling of speed the drag (force) quadruples per the formula. Exerting 4 times the force over a fixed distance produces 4 times as much work. At twice the speed the work (resulting in displacement over a fixed distance) is done twice as fast. Since power is the rate of doing work, 4 times the work done in half the time requires 8 times the power.

When the fluid is moving relative to the reference system (e.g. a car driving into headwind) the power required to overcome the aerodynamic drag is given by:Where is the wind speed and is the object speed (both relative to ground).

Velocity of a falling object

An object falling through viscous medium accelerates quickly towards its terminal speed, approaching gradually as the speed gets nearer to the terminal speed. Whether the object experiences turbulent or laminar drag changes the characteristic shape of the graph with turbulent flow resulting in a constant acceleration for a larger fraction of its accelerating time.

The velocity as a function of time for an object falling through a non-dense medium, and released at zero relative-velocity v = 0 at time t = 0, is roughly given by a function involving a hyperbolic tangent (tanh):The hyperbolic tangent has a limit value of one, for large time t. In other words, velocity asymptotically approaches a maximum value called the terminal velocity vt:For an object falling and released at relative-velocity v = vi at time t = 0, with vi < vt, is also defined in terms of the hyperbolic tangent function:For vi > vt, the velocity function is defined in terms of the hyperbolic cotangent function:The hyperbolic cotangent has also a limit value of one, for large time t. Velocity asymptotically tends to the terminal velocity vt, strictly from above vt.

For vi = vt, the velocity is constant:Actually, these functions are defined by the solution of the following differential equation:Or, more generically (where F(v) are the forces acting on the object beyond drag):For a potato-shaped object of average diameter d and of density ρobj, terminal velocity is aboutFor objects of water-like density (raindrops, hail, live objects—mammals, birds, insects, etc.) falling in air near Earth's surface at sea level, the terminal velocity is roughly equal towith d in metre and vt in m/s. For example, for a human body ( ≈0.6 m) ≈70 m/s, for a small animal like a cat ( ≈0.2 m) ≈40 m/s, for a small bird ( ≈0.05 m) ≈20 m/s, for an insect ( ≈0.01 m) ≈9 m/s, and so on. Terminal velocity for very small objects (pollen, etc.) at low Reynolds numbers is determined by Stokes law.

Terminal velocity is higher for larger creatures, and thus potentially more deadly. A creature such as a mouse falling at its terminal velocity is much more likely to survive impact with the ground than a human falling at its terminal velocity. A small animal such as a cricket impacting at its terminal velocity will probably be unharmed. This, combined with the relative ratio of limb cross-sectional area vs. body mass (commonly referred to as the square–cube law), explains why very small animals can fall from a large height and not be harmed.[22]

Very low Reynolds numbers: Stokes' drag

Trajectories of three objects thrown at the same angle (70°). The black object does not experience any form of drag and moves along a parabola. The blue object experiences Stokes' drag, and the green object Newton drag.

The equation for viscous resistance or linear drag is appropriate for objects or particles moving through a fluid at relatively slow speeds where there is no turbulence (i.e. low Reynolds number, ).[23] Purely laminar flow only exists up to Re = 0.1 under this definition. In this case, the force of drag is approximately proportional to velocity. The equation for viscous resistance is:[24]where:

  • is a constant that depends on both the material properties of the object and fluid, as well as the geometry of the object; and
  • is the velocity of the object.

When an object falls from rest, its velocity will bewhere:

  • is the density of the object,
  • is density of the fluid,
  • is the volume of the object,
  • is the acceleration due to gravity (i.e., 9.8 m/s), and
  • is mass of the object.

The velocity asymptotically approaches the terminal velocity . For a given , denser objects fall more quickly.

For the special case of small spherical objects moving slowly through a viscous fluid (and thus at small Reynolds number), George Gabriel Stokes derived an expression for the drag constant:where is the Stokes radius of the particle, and is the fluid viscosity.

The resulting expression for the drag is known as Stokes' drag:[25]For example, consider a small sphere with radius = 0.5 micrometre (diameter = 1.0 µm) moving through water at a velocity of 10 µm/s. Using 10−3 Pa·s as the dynamic viscosity of water in SI units, we find a drag force of 0.09 pN. This is about the drag force that a bacterium experiences as it swims through water.

The drag coefficient of a sphere can be determined for the general case of a laminar flow with Reynolds numbers less than using the following formula:[26]For Reynolds numbers less than 1, Stokes' law applies and the drag coefficient approaches !

Aerodynamics

In aerodynamics, aerodynamic drag (also known as air resistance) is the fluid drag force that acts on any moving solid body in the direction of the air freestream flow.[27] From the body's perspective (near-field approach), the drag results from forces due to pressure distributions over the body surface, symbolized , and forces due to skin friction, which is a result of viscosity, denoted . Alternatively, calculated from the flowfield perspective (far-field approach), the drag force results from three natural phenomena: shock waves, vortex sheet, and viscosity.

Overview

The pressure distribution acting on a body's surface exerts normal forces on the body. Those forces can be summed and the component of that force that acts downstream represents the drag force, , due to pressure distribution acting on the body. The nature of these normal forces combines shock wave effects, vortex system generation effects, and wake viscous mechanisms.

The viscosity of the fluid has a major effect on drag. In the absence of viscosity, the pressure forces acting to retard the vehicle are canceled by a pressure force further aft that acts to push the vehicle forward; this is called pressure recovery and the result is that the drag is zero. That is to say, the work the body does on the airflow is reversible and is recovered as there are no frictional effects to convert the flow energy into heat. Pressure recovery acts even in the case of viscous flow. Viscosity, however results in pressure drag and it is the dominant component of drag in the case of vehicles with regions of separated flow, in which the pressure recovery is fairly ineffective.

The friction drag force, which is a tangential force on the aircraft surface, depends substantially on boundary layer configuration and viscosity. The net friction drag, , is calculated as the downstream projection of the viscous forces evaluated over the body's surface.

The sum of friction drag and pressure (form) drag is called viscous drag. This drag component is due to viscosity. In a thermodynamic perspective, viscous effects represent irreversible phenomena and, therefore, they create entropy. The calculated viscous drag use entropy changes to accurately predict the drag force.

When the airplane produces lift, another drag component results. Induced drag, symbolized , is due to a modification of the pressure distribution due to the trailing vortex system that accompanies the lift production. An alternative perspective on lift and drag is gained from considering the change of momentum of the airflow. The wing intercepts the airflow and forces the flow to move downward. This results in an equal and opposite force acting upward on the wing which is the lift force. The change of momentum of the airflow downward results in a reduction of the rearward momentum of the flow which is the result of a force acting forward on the airflow and applied by the wing to the air flow; an equal but opposite force acts on the wing rearward which is the induced drag. Another drag component, namely wave drag, , results from shock waves in transonic and supersonic flight speeds. The shock waves induce changes in the boundary layer and pressure distribution over the body surface.

In summary, there are three ways of categorising drag.[28]: 19 

  1. Pressure drag and friction drag
  2. Profile drag and induced drag
  3. Vortex drag, wave drag and wake drag

History

The idea that a moving body passing through air or another fluid encounters resistance had been known since the time of Aristotle. According to Mervyn O'Gorman, this was named "drag" by Archibald Reith Low.[29] Louis Charles Breguet's paper of 1922 began efforts to reduce drag by streamlining.[30] Breguet went on to put his ideas into practice by designing several record-breaking aircraft in the 1920s and 1930s. Ludwig Prandtl's boundary layer theory in the 1920s provided the impetus to minimise skin friction. A further major call for streamlining was made by Sir Melvill Jones who provided the theoretical concepts to demonstrate emphatically the importance of streamlining in aircraft design.[31][32][33] In 1929 his paper ‘The Streamline Airplane’ presented to the Royal Aeronautical Society was seminal. He proposed an ideal aircraft that would have minimal drag which led to the concepts of a 'clean' monoplane and retractable undercarriage. The aspect of Jones's paper that most shocked the designers of the time was his plot of the horse power required versus velocity, for an actual and an ideal plane. By looking at a data point for a given aircraft and extrapolating it horizontally to the ideal curve, the velocity gain for the same power can be seen. When Jones finished his presentation, a member of the audience described the results as being of the same level of importance as the Carnot cycle in thermodynamics.[30][31]

Lift-induced drag and parasitic drag

Lift-induced drag

Lift-induced drag (also called induced drag) is drag which occurs as the result of the creation of lift on a three-dimensional lifting body, such as the wing or propeller of an airplane. Induced drag consists primarily of two components: drag due to the creation of trailing vortices (vortex drag); and the presence of additional viscous drag (lift-induced viscous drag) that is not present when lift is zero. The trailing vortices in the flow-field, present in the wake of a lifting body, derive from the turbulent mixing of air from above and below the body which flows in slightly different directions as a consequence of creation of lift.

With other parameters remaining the same, as the lift generated by a body increases, so does the lift-induced drag. This means that as the wing's angle of attack increases (up to a maximum called the stalling angle), the lift coefficient also increases, and so too does the lift-induced drag. At the onset of stall, lift is abruptly decreased, as is lift-induced drag, but viscous pressure drag, a component of parasite drag, increases due to the formation of turbulent unattached flow in the wake behind the body.

Parasitic drag

Parasitic drag, or profile drag, is drag caused by moving a solid object through a fluid. Parasitic drag is made up of multiple components including viscous pressure drag (form drag), and drag due to surface roughness (skin friction drag). Additionally, the presence of multiple bodies in relative proximity may incur so called interference drag, which is sometimes described as a component of parasitic drag.

In aviation, induced drag tends to be greater at lower speeds because a high angle of attack is required to maintain lift, creating more drag. However, as speed increases the angle of attack can be reduced and the induced drag decreases. Parasitic drag, however, increases because the fluid is flowing more quickly around protruding objects increasing friction or drag. At even higher speeds (transonic), wave drag enters the picture. Each of these forms of drag changes in proportion to the others based on speed. The combined overall drag curve therefore shows a minimum at some airspeed - an aircraft flying at this speed will be at or close to its optimal efficiency. Pilots will use this speed to maximize endurance (minimum fuel consumption), or maximize gliding range in the event of an engine failure.

Power curve in aviation

The power curve: parasitic drag and lift-induced drag vs. airspeed

The interaction of parasitic and induced drag vs. airspeed can be plotted as a characteristic curve, illustrated here. In aviation, this is often referred to as the power curve, and is important to pilots because it shows that, below a certain airspeed, maintaining airspeed counterintuitively requires more thrust as speed decreases, rather than less. The consequences of being "behind the curve" in flight are important and are taught as part of pilot training. At the subsonic airspeeds where the "U" shape of this curve is significant, wave drag has not yet become a factor, and so it is not shown in the curve.

Wave drag in transonic and supersonic flow

Qualitative variation in Cd factor with Mach number for aircraft

Wave drag (also called compressibility drag) is drag that is created when a body moves in a compressible fluid and at speeds that are close to the speed of sound in that fluid. In aerodynamics, wave drag consists of multiple components depending on the speed regime of the flight.

In transonic flight (Mach numbers greater than about 0.8 and less than about 1.4), wave drag is the result of the formation of shockwaves in the fluid, formed when local areas of supersonic (Mach number greater than 1.0) flow are created. In practice, supersonic flow occurs on bodies traveling well below the speed of sound, as the local speed of air increases as it accelerates over the body to speeds above Mach 1.0. However, full supersonic flow over the vehicle will not develop until well past Mach 1.0. Aircraft flying at transonic speed often incur wave drag through the normal course of operation. In transonic flight, wave drag is commonly referred to as transonic compressibility drag. Transonic compressibility drag increases significantly as the speed of flight increases towards Mach 1.0, dominating other forms of drag at those speeds.

In supersonic flight (Mach numbers greater than 1.0), wave drag is the result of shockwaves present in the fluid and attached to the body, typically oblique shockwaves formed at the leading and trailing edges of the body. In highly supersonic flows, or in bodies with turning angles sufficiently large, unattached shockwaves, or bow waves will instead form. Additionally, local areas of transonic flow behind the initial shockwave may occur at lower supersonic speeds, and can lead to the development of additional, smaller shockwaves present on the surfaces of other lifting bodies, similar to those found in transonic flows. In supersonic flow regimes, wave drag is commonly separated into two components, supersonic lift-dependent wave drag and supersonic volume-dependent wave drag.

The closed form solution for the minimum wave drag of a body of revolution with a fixed length was found by Sears and Haack, and is known as the Sears-Haack Distribution. Similarly, for a fixed volume, the shape for minimum wave drag is the Von Karman Ogive.

The Busemann biplane theoretical concept is not subject to wave drag when operated at its design speed, but is incapable of generating lift in this condition.

d'Alembert's paradox

In 1752 d'Alembert proved that potential flow, the 18th century state-of-the-art inviscid flow theory amenable to mathematical solutions, resulted in the prediction of zero drag. This was in contradiction with experimental evidence, and became known as d'Alembert's paradox. In the 19th century the Navier–Stokes equations for the description of viscous flow were developed by Saint-Venant, Navier and Stokes. Stokes derived the drag around a sphere at very low Reynolds numbers, the result of which is called Stokes' law.[34]

In the limit of high Reynolds numbers, the Navier–Stokes equations approach the inviscid Euler equations, of which the potential-flow solutions considered by d'Alembert are solutions. However, all experiments at high Reynolds numbers showed there is drag. Attempts to construct inviscid steady flow solutions to the Euler equations, other than the potential flow solutions, did not result in realistic results.[34]

The notion of boundary layers—introduced by Prandtl in 1904, founded on both theory and experiments—explained the causes of drag at high Reynolds numbers. The boundary layer is the thin layer of fluid close to the object's boundary, where viscous effects remain important even when the viscosity is very small (or equivalently the Reynolds number is very large).[34]

See also

References

  1. ^ "Definition of DRAG". Merriam-Webster. Retrieved 2023-05-07.
  2. ^ French (1970), p. 211, Eq. 7-20
  3. ^ a b "What is Drag?". Archived from the original on 2010-05-24. Retrieved 2011-10-16.
  4. ^ Eiffel, Gustave (1913). The Resistance of The Air and Aviation. London: Constable &Co Ltd.
  5. ^ Marchaj, C. A. (2003). Sail performance : techniques to maximise sail power (Rev. ed.). London: Adlard Coles Nautical. pp. 147 figure 127 lift vs drag polar curves. ISBN 978-0-7136-6407-2.
  6. ^ Drayton, Fabio Fossati; translated by Martyn (2009). Aero-hydrodynamics and the performance of sailing yachts : the science behind sailing yachts and their design. Camden, Maine: International Marine /McGraw-Hill. pp. 98 Fig 5.17 Chapter five Sailing Boat Aerodynamics. ISBN 978-0-07-162910-2.{{cite book}}: CS1 maint: multiple names: authors list (link)
  7. ^ "Calculating Viscous Flow: Velocity Profiles in Rivers and Pipes" (PDF). Retrieved 16 October 2011.
  8. ^ "Viscous Drag Forces". Retrieved 16 October 2011.
  9. ^ Hernandez-Gomez, J J; Marquina, V; Gomez, R W (25 July 2013). "On the performance of Usain Bolt in the 100 m sprint". Eur. J. Phys. 34 (5): 1227–1233. arXiv:1305.3947. Bibcode:2013EJPh...34.1227H. doi:10.1088/0143-0807/34/5/1227. S2CID 118693492. Retrieved 23 April 2016.
  10. ^ Encyclopedia of Automotive Engineering, David Crolla, Paper "Fundamentals, Basic principles in Road vehicle Aerodynamics and Design", ISBN 978 0 470 97402 5
  11. ^ The Design Of The Aeroplane, Darrol Stinton, ISBN 0 632 01877 1, p.204
  12. ^ Fundamentals of Flight, Second Edition, Richard S. Shevell,ISBN 0 13 339060 8, p.185
  13. ^ A Case Study By Aerospatiale And British Aerospace On The Concorde By Jean Rech and Clive S. Leyman, AIAA Professional Study Series, Fig. 3.6
  14. ^ Design For Air Combat, Ray Whitford,ISBN 0 7106 0426 2, p.212
  15. ^ For Earth's atmosphere, the air density can be found using the barometric formula. It is 1.293 kg/m3 at 0 °C and 1 atmosphere.
  16. ^ a b Liversage, P., and Trancossi, M. (2018). "Analysis of triangular sharkskin profiles according to second law", Modelling, Measurement and Control B. 87(3), 188-196.
  17. ^ Size effects on drag Archived 2016-11-09 at the Wayback Machine, from NASA Glenn Research Center.
  18. ^ Wing geometry definitions Archived 2011-03-07 at the Wayback Machine, from NASA Glenn Research Center.
  19. ^ Roshko, Anatol (1961). "Experiments on the flow past a circular cylinder at very high Reynolds number" (PDF). Journal of Fluid Mechanics. 10 (3): 345–356. Bibcode:1961JFM....10..345R. doi:10.1017/S0022112061000950. S2CID 11816281.
  20. ^ a b Batchelor (1967), p. 341.
  21. ^ Brian Beckman (1991), Part 6: Speed and Horsepower, archived from the original on 2019-06-16, retrieved 18 May 2016
  22. ^ Haldane, J.B.S., "On Being the Right Size" Archived 2011-08-22 at the Wayback Machine
  23. ^ Drag Force Archived April 14, 2008, at the Wayback Machine
  24. ^ Air friction, from Department of Physics and Astronomy, Georgia State University
  25. ^ Collinson, Chris; Roper, Tom (1995). Particle Mechanics. Butterworth-Heinemann. p. 30. ISBN 9780080928593.
  26. ^ tec-science (2020-05-31). "Drag coefficient (friction and pressure drag)". tec-science. Retrieved 2020-06-25.
  27. ^ Anderson, John D. Jr., Introduction to Flight
  28. ^ Gowree, Erwin Ricky (20 May 2014). Influence of Attachment Line Flow on Form Drag (doctoral). Retrieved 22 March 2022.
  29. ^ https://archive.org/details/Flight_International_Magazine_1913-02-01-pdf/page/n19/mode/2up Flight, 1913, p. 126
  30. ^ a b Anderson, John David (1929). A History of Aerodynamics: And Its Impact On Flying Machines. University of Cambridge.
  31. ^ a b "University of Cambridge Engineering Department". Retrieved 28 Jan 2014.
  32. ^ Sir Morien Morgan, Sir Arnold Hall (November 1977). Biographical Memoirs of Fellows of the Royal Society Bennett Melvill Jones. 28 January 1887 -- 31 October 1975. Vol. 23. The Royal Society. pp. 252–282.
  33. ^ Mair, W.A. (1976). Oxford Dictionary of National Biography.
  34. ^ a b c Batchelor (2000), pp. 337–343.
  • 'Improved Empirical Model for Base Drag Prediction on Missile Configurations, based on New Wind Tunnel Data', Frank G Moore et al. NASA Langley Center
  • 'Computational Investigation of Base Drag Reduction for a Projectile at Different Flight Regimes', M A Suliman et al. Proceedings of 13th International Conference on Aerospace Sciences & Aviation Technology, ASAT- 13, May 26 – 28, 2009
  • 'Base Drag and Thick Trailing Edges', Sighard F. Hoerner, Air Materiel Command, in: Journal of the Aeronautical Sciences, Oct 1950, pp 622–628

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