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The [[Epigenetics|epigenetics]] of [[Schizophrenia|schizophrenia]] is the study of how the environment and external factors shape and influence |
The [[Epigenetics|epigenetics]] of [[Schizophrenia|schizophrenia]] is the study of how the environment and external factors shape and influence |
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the onset and development of, and vulnerability to the psychological and neurological disorder, schizophrenia. |
the onset and development of, and vulnerability to the psychological and neurological disorder, schizophrenia. |
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== Background == |
== Background == |
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=== Heritability=== |
=== Heritability=== |
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===Environmental Risks=== |
===Environmental Risks=== |
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===Epigenetic Mechanisms=== |
===Epigenetic Mechanisms=== |
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[[File:Epigenetic mechanisms.jpg |thumb| alt=Alternative text, Mechanisms of Epigenetics|Mechanisms of Epigenetics in the Cell]] |
[[File:Epigenetic mechanisms.jpg |thumb| alt=Alternative text, Mechanisms of Epigenetics|Mechanisms of Epigenetics in the Cell]] |
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====Other Mechanisms==== |
====Other Mechanisms==== |
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===Methods of Research=== |
===Methods of Research=== |
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These include cellular and molecular genetic studies, mass genomic computational studies, transgenic and diseased animal models, and postmortem tissue analyses, one of the only current ways to study epigenetics in human schizophrenics. <ref name="Roth"/> |
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==Molecular Mechanisms== |
==Molecular Mechanisms== |
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==Future Directions and Potential== |
==Future Directions and Potential== |
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== All about citations == |
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First citation, which only once. <ref name="Roth"> Roth, T.L., Lubin, F.D., Sodhi, M., Kleinman, J. E., 2009, Epigenetic Mechanisms in Schizophrenia, Biochimica et Biophysica Acta, Vol. 1790, 869-77.</ref> |
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Here is the second time using Bongard citation. Can do it like first time or ... <ref name="van Os"/> |
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== References == |
== References == |
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Revision as of 02:37, 27 September 2012
The epigenetics of schizophrenia is the study of how the environment and external factors shape and influence the onset and development of, and vulnerability to the psychological and neurological disorder, schizophrenia. It is a severely debilitating and misunderstood disease that affects nearly 1% of the world population[1].
Background
History
Heritability
Environmental Risks
Advanced paternal age is one of the risk factors for schizophrenia, according to recent research. This is possibly through mutagenesis, which cause further spontaneous changes, or through genomic imprinting [2]
Epigenetic Mechanisms
DNA Methylation
Histone Modification
Other Mechanisms
Methods of Research
These include cellular and molecular genetic studies, mass genomic computational studies, transgenic and diseased animal models, and postmortem tissue analyses, one of the only current ways to study epigenetics in human schizophrenics. [1]
Molecular Mechanisms
DNA Methylation
Histone Modifications
Other
Behavioral Effects
Limitations
Future Directions and Potential
References
- ^ a b Roth, T.L., Lubin, F.D., Sodhi, M., Kleinman, J. E., 2009, Epigenetic Mechanisms in Schizophrenia, Biochimica et Biophysica Acta, Vol. 1790, 869-77.
- ^ van Os, J., Rutten, B., Poulton, R., 2008, Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions, Schizophrenia Bulletin, Vol. 34, 1066-1082.
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This page was last edited by Gazirashid (talk | contribs) 12 years ago. (Update timer) |