Википедија

ACEA-1328

ACEA-1328 je antagonist NMDA receptora, koji akutno pojačava antinocicepciju i hronično smanjuje toleranciju izazvanu morfijumom.[3][4]

ACEA-1328
6,7-Dimethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dione
Nazivi
Preferisani IUPAC naziv
6,7-dimetil-5-nitro-1,4-dihidrohinoksalin-2,3-dion
Drugi nazivi
  • ACEA 1328
  • CHEMBL41460
  • 6,7-dimethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dione
  • SCHEMBL7471983
  • SCHEMBL8113307
  • BDBM50056595
  • 1,4-dihydro-6,7-dimethyl-5-nitroquinoxalin-2,3-dione
  • 6,7-Dimethyl-5-nitro-1,4-dihydro-quinoxaline-2,3-dione
  • 1,4-dihidro-6,7-dimetil-5-nitrohinoksalin-2,3-dion
  • 6,7-Dimetil-5-nitro-1,4-dihidro-hinoksalin-2,3-dion
  • 5-nitro-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione
  • 5-nitro-6,7-dimetil-1,4-dihidro-2,3-hinoksalindion
Identifikacija
3D model (Jmol)
  • CC1=CC2=C(C(=C1C)[N+](=O)[O-])NC(=O)C(=O)N2
Svojstva
C10H9N3O4
Molarna masa 235,20 g·mol−1
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Reference infokutije

Reference

уреди
  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  2. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. ^ K. Lutfy; P. Doan; E. Weber (1999). „ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine”. Pharmacol. Res. 40: 435—442. 
  4. ^ E. Ozdemir; I. Bagcivan; S. Gursoy (2012-06-01). „Modulation of Morphine Analgesia and Tolerance in Rats by NMDA Receptor Antagonists”. Neurophysiology. 44: 123—130. doi:10.1007/s11062-012-9278-9. 
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