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Benadryl

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This is an old revision of this page, as edited by Bubbachuck (talk | contribs) at 11:39, 1 June 2009 (histamine is a vasodilator, antihistamine is a vasoconstrictor). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Benadryl is a brand name allergy medicine manufactured by McNeil Healthcare (UK) Limited. Benadryl is used as an antihistamine for the temporary relief of seasonal and perennial allergy symptoms. Benadryl is available for oral or topical use.

In the U.S. Benadryl products contain the 1st generation antihistamine Diphenhydramine. Diphenhydramine is used as an allergy treatment in various forms around the world. Diphenhydramine is an H-1 receptor antagonist. Antagonism is achieved through blocking the effect of histamine more than blocking its production or release. Diphenhydramine inhibits most responses of smooth muscle to histamine and acts as a vasoconstrictor by inhibiting the vasodilator effects of histamine. The antagonism may also produce anticholinergic effects, antiemetic effects, and significant sedative side effects.

In the United Kingdom Benadryl products contain either the 2nd generation antihistamine acrivastine (sold as Benadryl Allergy Relief) or the antihistamine cetirizine (sold as Benadryl Once a Day). Cetirizine is indicated for the relief of symptoms associated with allergy and hives. Cetirizine is an orally active and selective H1-receptor antagonist.

Benadryl products are marketed in Australia and New Zealand by Johnson & Johnson Pacific.

References

  • "Benadryl (Diphenhydramine) Drug Information". RXList. 2009. Retrieved 2009-03-06.
  • "Drugs and Human Performance Fact Sheets: Diphenhydramine". National Highway Traffic and Safety Administration. 06 May 2004. Retrieved 2009-03-06. {{cite web}}: Check date values in: |date= (help)
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