Atomic structure of the actin:DNase I complex
- PMID: 2395459
- DOI: 10.1038/347037a0
Atomic structure of the actin:DNase I complex
Abstract
The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
Comment in
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Protein structure. The changing shape of actin.Nature. 1990 Sep 6;347(6288):21-2. doi: 10.1038/347021a0. Nature. 1990. PMID: 2244943 No abstract available.
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