SERPIND1

SERPIND1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JMO, 1JMJ, 2NAT
Dynodwyr
Cyfenwau	SERPIND1, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10, serpin family D member 1
Dynodwyr allanol	OMIM: 142360 HomoloGene: 36018 GeneCards: SERPIND1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • endopeptidase inhibitor activity • heparin binding • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • extracellular exosome • extracellular space • endoplasmic reticulum lumen • extracellular region Prosesau biolegol • negative regulation of peptidase activity • Bywoleuni • hemostasis • chemotaxis • blood coagulation • negative regulation of endopeptidase activity • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3053	n/a
Ensembl	ENSG00000099937	n/a
UniProt	P05546	n/a
RefSeq (mRNA)	NM_000185	n/a
RefSeq (protein)	NP_000176	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPIND1 yw SERPIND1 a elwir hefyd yn Serpin family D member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.21.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPIND1.

• "Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer. ". J Pathol. 2015. PMID 25130770.
• "The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand. ". BMC Biochem. 2013. PMID 23496873.
• "Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors. ". Hypertens Res. 2011. PMID 21107326.
• "Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. ". Exp Mol Pathol. 2009. PMID 19747479.
• "Plasma heparin cofactor II activity is an independent predictor of future cardiovascular events in patients after acute myocardial infarction.". Coron Artery Dis. 2008. PMID 18971786.