Uploadvirus

Hello everyone 👍. My name is Cliff L. Knickerbocker, but I've been known by other editors by my Username - which is "Uploadvirus" - ever since my first edits in 2009.

I'm now 64 and currently semi-retired for 2 years, as I prepare for my last venture, which will be a non-profit clinical genomics research and consulting firm. My family and I also plan to open a related nonprofit charity, to be called "The Knickerbocker Family Memorial Children's Charity" (see section below). Our goal is to provide a variety of networking, referral, educational, financial, and targeted research services to kids, families, childcare workers, and other local and regional stakeholders, focusing on genomic disorders, cancers, and rare diseases.

I also continue to do some legal and forensic work in both civil and criminal cases, and teach as much as I can.

As of this update (October 2024), I'm living in the small city of Marion, in Southern Illinois, USA 🇺🇲, where I was raised and graduated from high school, the Great Class of 1978.

If you'd like to know more about me, my research, or my charity, then please feel free to contact me through Facebook, Messenger, Telegram, or via my personal email accounts at:
genome_research@yahoo.com, or

cliffknickerbocker1960@gmail.com, or
uploadvirus@yahoo.com.

You can - if you like to do things the easy way - just call my cell phone at 816-259-8783 any time of day or night (we are in the Central time zone = GMT+6 hr).

Summary of personal and business contact information:

Cliff L. Knickerbocker BSCh MS DDF
Adnomery Research Company
208 East Charles Street
Marion, IL 62959
HOME/OFC: 816-259-8783
CELL/TEXT: 816-977-3674

I've written 33 new articles, some related to general [[oncology], but most relevant to areas of my research expertise, which is the many rare histological variants of non-small cell carcinoma. One of my articles, on combined small cell carcinoma of the lung, won the "Outstanding Newcomer Award" from my colleagues at the English Wikipedia. It was quite an honor for me, and I'm grateful for the consideration and kindness of those responsible for that.

I've also spent considerable time doing major and minor revisions to clinical oncology-related content, with particular emphasis on my career research specialty, the numerous histological and molecular variants of lung cancer known as the "non-small cell lung carcinomas".

I've also been involved with some peer reviews, have done award-winning work with the Wikipedia Guild of Copy Editors, been a part of the Wikipedia Typo Team, and have served for well over a decade as a New Pages Reviewer, Recent Changes Patroller, Vandalism Patroller, and a Rollbacker.

I've also served 3 one-year terms on the Board of Directors of Wikipedia Project Medicine (2019-2020, 2020-2021, and 2021-2022). I've put in some time on the Pulmonology Task Force, and also help out with the Pharmacology, Cellular and Molecular Biology, Microbiology, and Anatomy Projects here.

In October 2020, I had a paradigm shift in my research emphasis (see below). After 44 years of lung cancer research, I've decided to go back to my first focus - pediatric genomics and human chromosomal abnormalities. My emphasis so far has been on copy number variants, particularly microduplications involving the acrocentric autosomes (mostly number 15, but also 13, 14, 21, and 22), and I will be contributing as much as I can, when I can, to the Wikipedia Neuroscience Initiative. I plan to soon expand a number of stubs into up to date, comprehensive articles pure partial trisomies of various autosomes.

I am semi-retired now, but I continue to operate a small private research, education, teaching, and consulting firm called Adnomery Research Company (ARC), here in Marion, Illinois, where I have lived with my wife, Jackie Ward, from 2017 to the present (March 2022).

My idiosyncrasies and breadth of interests have led me to pursue many varied challenges during my professional career. Over the past 45 years, I've worked as a mining engineer (1973-1985), a research virologist specializing in cloning and tissue culture of herpes and pox viruses in human and other mammalian epithelial tissues (1985-1986), a forensic chemist (1986-1989), a project manager for a large construction company draglines (1989-1993), a private investigator and forensic consultant (1993-2012), a radiology patient care technician (2001-2003), an epidemiology researcher and graduate school lecturer, and research Fellow at the University of Arkansas (2002-2006), a medical researcher specializing in rare histotypes if lung cancer (1997-2012), a forensic and medical expert and consultant for various law firms (1993-2012), and a clinical genomics researcher (2020-2023).

My current (as of September 2023) research focus is in clinical pediatric genomics, with an emphasis on (1) human syndromes and genomic issues caused by specific cytogenetic microduplication syndromes, (2) phenotypic gene dosage effects, (3) "in cis-" and "in trans-" genetic regulatory effects of coding gene deserts in both up- and downstream coordinate dimensions of various chromosomal anomalies, and the Human Varisome Project.

I'm concentrating more deeply on the genomics and clinical trials of specific to phenotypes of children with pure and mixed partial distal trisomies of human chromosome band 15q21.1, with a special interest in direct interstitial tandem duplications involving base pair coordinates 45.5 Mb to 47.0 Mb. For these latter duplications, which include the coding gene desert "HGD15q21.1:45.50-47.00", I have proposed the subgroup scientific portmanteau of "Hadlee-Beth Microduplications" (see below section).

For more information, please see our preprints entitled "Proposed Classification System for Pure Partial Distal Trisomies of Human Band 15q21.1

CASE HQW: CMA Genotype 46,XX, dup (15) (q21.1, q21.1); dup 15q21.1 (45,767,342-46,789,177) x 3.

PHENOTYPE: Global Developmental Delay, Intellectual Disability, Autism Spectrum Disorder, Macrocephaly/Macrosomia, Arachnodactyly, Strabismus (Esotropia), Ataxic Gait, Pica, Relative Pain Insensitivity, Sleep Disturbance, Chronic Constipation, Toxic Megacolon, Possible Novel CCD3, Possible FBN-1 Haploinsufficiency.

• Full and Partial Trisomies in the Genome of the Human: Clinical Consequences and Potential Interventions

I spent most of my life (1976 to 2020) focusing my research on the molecular biology and genetics of non-small cell lung cancers, particularly those in rare histological subtypes and variants.

In February of 2015, however, my youngest granddaughter - who I call "Princess Hadlee" - was born after an uncomplicated (para 2 gravida 2) pregnancy, to my youngest daughter, who was a promising first year nursing student.

Although she appeared robustly healthy from birth, it became apparent in her first year of life that she had signs of a mild muscular hypotonia, craniofacial dysmorphisms, and a global developmental delay.

My daughter acted quickly and bravely to get her tested, and she was diagnosed on 2017 with classical juvenile autism by experts at Southern Illinois University in Carbondale.

It was later confirmed by doctors at St. Louis Children's Hospital that my "Youngest Princess" indeed had some signs and symptoms of a possible syndromic neurodevelopmental disorder (NDD) featuring stereotypical behaviors and communications disorders consistent with autism.

After a brief bout of acutely increased intracranial pressure in 2020, we worried about the possibility of cranioisotosis, so she was screened for genomic variants in her DNA by array comparative genomic hybridization (a-CGH).

The screening showed that she has a duplication of a portion of the genetic material in the long arm of chromosome number 15 - more specifically, an interstitial duplication in subband 1 of band 1 of region 2 (ish dup 15q21.1), with genotype (per Paris standard) of 46, XX, dup ish (15) (q21.1, q21.1). To date, I have not been made aware of the exact chromosomal coordinates of the breakpoints.

I wrote my masters thesis on mortality trends in skeletal system sarcomas, including osteosarcoma, chondrosarcoma, and Ewing's sarcoma. I have also published, and/or presented at professional conferences, a number of studies that examined risk factors for developing cancers of the female reproductive system (and other organs). One of these, which was published in the American Journal of Health Education in 2003, has been designated as "Required Reading" at Johns Hopkins University.

I've also done some interesting work in geographic trend analysis of mortality due to cerebrovascular and cardiovascular diseases.

About 15 years ago, when I was at the U of A, Dr. Michael Young (now Dean of Research at New Mexico State University) and I did some non-linear mortality trend analyses of age-adjusted death rates from stroke. At the time, official data suggested Arkansas had (only) the 11th highest stroke death rate amongst the 50 US states. However, our trend analyses suggested it was already #1, or would be very soon. Within just a couple of years, new data showed we were correct! Partly because we were so busy doing other things, but mostly because of the intensely negative political fallout that publication of such a study would no doubt have generated, we never did submit our work for publication.

I have broad and diverse miscellaneous academic and professional interests, but have the most expertise in pathology, pharmacology, pharmaceutical chemistry, toxicology, cosmology, astrophysics, mathematics, statistics, nuclear weapons, military science, politics, forensic science, criminal law, and theology.

When it comes to sports, I enjoy college football (particularly the Arkansas Razorbacks), powerlifting, Olympic weightlifting, boxing, mixed martial arts, and bodybuilding.

I grew up in the coal mines with my Dad, and started working for him in the 7th grade - laboring, blasting, and operating heavy equipment (i.e. bulldozers, end loaders, and draglines). I became a fan of "walking draglines" and surface mining at a young age, and for many years (off-and-on) I helped build and work on draglines, mostly as a Project Manager for the White Equipment Corporation. You can see one of the machines I helped put together in two videos, located here [[1]] and here [[2]]. It is a specially modified Rapier W2000. It was, at the time, the largest of its kind ever built.

The original machine was purchased and disassembled in Pottsville, Pennsylvania over several months, then transported to Bessemer, Pennsylvania in a total of 188 individual tractor-trailer loads. During the reassembly, we lengthened the boom from 285 to 315 feet and added a bigger bucket (45 cubic yards, instead of 30). This upsizing required extensive engineering modifications to the ballast, hoist and drag drums, house, and swing gear support structures to allow for much heavier stresses. This unique and awesome machine was then re-erected for the ESSROC Corporation between 1991 and 1993, with the Bucyrus-Erie/MINSERCO Corporation and British engineers and electricians assisting with parts of the erection and commissioning processes. The entire (huge) job ran for about 30 months, involved more than 30 employees, and was budgeted at over $2 million. Unfortunately, I recently found out that this beauty has been idle for at least 2 years now, and will probably be scrapped at the site.

I earned a Bachelor of Science degree in Chemistry from the Missouri University of Science and Technology (formerly the University of Missouri-Rolla). My emphasis areas included biochemistry, pharmaceutical chemistry, and the life sciences. During my undergraduate studies, I worked for a semester as an intern in the laboratory of Dr. Donald Siehr, researching the molecular genetics of the beta-lactamase operon in Saccharomyces cerevisiae.

After graduating with my B.S., I attended Southern Illinois University-Carbondale for one year, taking graduate courses in immunology, virology, molecular biology, and microbiology. From 1985-86, I worked as a virology researcher in the Southern Illinois Cancer Research Laboratory under the direction of Dr. Hassan Rouhandeh, studying the oncogenicity and pathology of Herpes and Poxviruses in epithelial cell tissue culture. I left SIU-C in 1986 to take a job as a forensic chemist with the Illinois Bureau of Forensic Sciences, specializing in the analysis of pharmaceuticals, illicit drugs, and general chemical unknowns. I also served on two statewide Forensic Chemistry Section Committees (the Quantitation Committee and the Quality Control Committee), and also conducted some research developing new methods for rapid semi-quantitative analyses of cocaine and heroin using gas chromatography-mass spectrometry with ion trap detection (GC-MS/ITD). In 1987, I sat for a non-credit graduate course in mammalian cloning at the University of Illinois-Springfield.

I later earned a Master of Science degree in Health Science from the University of Arkansas. My emphasis area was in cancer epidemiology, with particular foci in the clinical epidemiology of unusual variants of lung cancer and mortality trends due to skeletal system cancers (sarcoma using non-linear modeling techniques. My masters thesis was entitled "Skeletal Sarcoma Mortality Trends in Arkansas are Confounded by Misdiagnosis of Fatal Lung Cancer Cases in the Oldest Old". During my masters program, I was elected to Phi Kappa Phi, graduated #1 in my class, was voted the "Most Outstanding Masters Student" award, and was awarded a Northwest Arkansas Cancer Challenge Fellowship in lung cancer epidemiology. The latter honor allowed me to spend part of a summer studying lung cancer epidemiology at the The Johns Hopkins University School of Medicine and the Bloomberg School of Public Health.

While at the University of Arkansas, I was the Assistant Director of the Health Education Projects Office, under one of the most accomplished health science researchers in the world, Dr. Michael E. Young. As a team, we conducted considerable research into risk factors for gynecological cancers, stroke mortality trends in Arkansas and the "stroke belt", and drug use and pregnancy prevention among teenagers. I also helped Dr. Young revise and update his nationally recognized and honored drug prevention program, "Keep a Clear Mind".

After completing my masters degree, I won the first Walton Distinguished Doctoral Fellowship in Health Science that was ever granted at the U of A. After completing four years of this teaching and research fellowship, working with Dr. Michael E. Young, and doing an internship in the Human Performance Laboratory under Dr. Ro DiBrezzo, I returned home to Illinois to help take care of my aging parents, and to (slowly) complete my dissertation and (eventually) obtain my Ph.D. degree.

Child of Veterans Academic Scholarship

University of Illinois at Urbana-Champaign

$40,000 scholarship over 4 years

Declined because my father wanted me to attend the University of Missouri-Rolla

Kappa Mu Epsilon Mathematics Honor Fraternity

Elected to membership, University of Missouri-Rolla Chapter

For being in top 10% of mathematics students in U.S.

Walton Distinguished Doctoral Fellowship in Health Science

University of Arkansas, College of Health Professions

$120,000 cash grant (plus tuition) over 4 years

For outstanding research and teaching potential in health science

Specializations in lung cancer and skeletal sarcomas

Northwest Arkansas Cancer Challenge Education Grant

Johns Hopkins University School of Medicine

Johns Hopkins University Bloomberg School of Public Health

$4,000 cash grant over 3 months

For advanced education in lung cancer epidemiology

Teaching Assistant Training Award (won twice)

University of Arkansas, Center for Excellence in Teaching

$650 cash grant over 2 years

For outstanding overall teaching and training effectiveness

21st Annual Graduate Institute of Epidemiology and Biostatistics

Johns Hopkins University School of Medicine

Bloomberg School of Public Health

Department of Epidemiology and Biostatistics

$2,500 cash grant over one month

For advanced study in lung cancer prevention

Outstanding Masters Degree Student in Health Science Award

University of Arkansas, College of Education and Health Professions (declined the award

ned award athe Waltoninning Walton Distinguish)ed Fellowship

Phi Kappa Phi Honor Fraternity

Elected for being in top 2% of graduate students in the U.S.

Northwest Arkansas Cancer Challenge Research Grant

With Dr. Michael E. Young, Ph.D. (Principal Investigator)

$8,000 cash grant for a one year project "Setting the [Research] Agenda"

For developing research proposals in lung cancer prevention

I created and wrote (nearly) all of the substantive information in the following three articles myself. The first two were submitted to (successful) peer review, and the third will be when it is completely finished. I think I can make a good argument that these articles are more comprehensive sources than any other that is currently available in the world literature (as of August 2012).

• Combined small cell lung carcinoma

• Large cell lung carcinoma with rhabdoid phenotype

• Giant cell carcinoma of the lung

Most contributors and administrators here at Wikipedia have been exceptionally kind to me, and a few have even awarded me with particular accolades, which I display here with much gratitude

Some of the writing I've done here at Wikipedia has (apparently) been plagiarized verbatim in the peer-reviewed literature! Here are cites for a few examples I've run across:

Krishnamurthy A, Vijayalakshmi N, Majhi U. A fatal case of pure giant cell carcinoma of the lung. J Can Res Ther 2011;7:363-5. - the authors copied and used part of an introduction I first wrote for my award-winning article on combined small cell lung carcinoma, and that I also used in several other articles.

Krčedinac J, Panjković M, Božanić S, Samardžija G, Stojanović M. Large cell lung carcinoma with rhabdoid phenotype: Case report. Arch Oncol 2011;19:34-6. - in their conclusion, the authors copied from my large cell lung carcinoma with rhabdoid phenotype Wikipedia article.

Google searches of various phrases reveal many other examples. Please, folks - when you use someone else's work, just give them credit with a cite! That's all we researchers ask!

• "It is not the critic who counts - not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood, who strives valiantly, who errs, who comes up short, again and again, because he knows there is no real effort without both error and shortcoming. But those who actually strive to do these deeds, who know the great enthusiasms, and the great devotions, and who spends himself completely in a worthy cause. Who at the best, knows in the end the great triumphs of very high achievement, but who at the worst - if he fails - at least he fails while daring greatly, so that HIS place shall NEVER be with those cold and timid souls who never know neither victory nor defeat" - Theodore Roosevelt

• "We make a living by what we get, we make a life by what we give" - Winston Churchill

• "I would be the most content if my children grew up to be the kind of people who think decorating consists mostly of building enough bookshelves" - Anna Quindlen

• "The Honorable General" is the first person to step foot on the battlefield, and the last to leave it - whether standing on his feet, or lying in his body bag. He is the first to dig a shovelful of Earth, and the last to take credit for the improvements wrought. He makes certain his troops are well fed, clad, and rested before takes a mouthful of sustenance, dons his field jacket, or places his head upon his pillow. During a struggle, The Honorable General dedicates himself to educating his troops as to their great might and even greater worth. He continuously assures them of the righteousness of their campaign, and of its inevitable success. He constantly provides all members of his command with the tools and the personal leadership they need to be victorious. If the battle turns against him, he is the first to claim the fault for himself, and the last to criticize the performance of his followers. When the battle is finally won, he is the first to offer praise to those who persevered under his flawed command, and the last to claim responsibility for the fruits of their victory. Most importantly, The Honorable General never forgets that his ultimate duty is to strive to funnel all available resources into the hearts and heads of his troops - for in only that way can he insure, beyond doubt, not just that his troops will conquer all, but that they will always strive to remain as honorable as he is." - Cliff Knickerbocker ... for Damon Ward: this is my only son, of whom I am very proud (said to Jesus by God the Father, as the Son suffered and died on the Cross).

My Beloved (Pro) Sister: Roger ("Rogie") Knickerbocker BSW MSW (b. 16 March 1962, with God 2023)

Visit the Rogie Knickerbocker Foundation for Special Needs Children at *insert final active 🔗 here*

My Mother: Esther Mae Knickerbocker (b. 14 April 1932, d. 24 March 2010)

My Father: Roger Cliff Knickerbocker (b. 19 June 1915, d. 6 February 1977)

My Stepfather: Frank L. White (b. 11 July 1922, d. 14 December 2010)

My Interim Father: Dr. Ronald Browning, Ph.D. (b. 24 April 1934, d. 27 April 1992)

My Research Father: Dr. Michael E. Young, Ph.D. (b. 26 March 1950, fl. 2020)

My Second Mother: ("Nana") Ora Helen Sherrod Ritsch (b. 21 May 1904, d. 1 February 2002)

Cliff L. Knickerbocker, BSCh MS DDF

President/Senior Analyst

Adnomery Research Company

Marion, IL 62959

TEL: (816) 259-8783