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Aquaporin-7

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AQP7
Identifiers
AliasesAQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDsOMIM: 602974; MGI: 1314647; HomoloGene: 48000; GeneCards: AQP7; OMA:AQP7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007473

RefSeq (protein)
Location (UCSC)Chr 9: 33.38 – 33.4 MbChr 4: 41.03 – 41.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.[5][6]

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165269Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028427Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID 9252401.
  6. ^ a b "Entrez Gene: AQP7 aquaporin 7".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.