Cyclin-dependent kinase 10

CDK10
Identifiers
Aliases	CDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDs	OMIM: 603464; MGI: 2448549; HomoloGene: 55769; GeneCards: CDK10; OMA:CDK10 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,696,354 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,958,989 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; body of pancreas; ; right lobe of liver; ; granulocyte; ; mucosa of transverse colon; ; apex of heart; ; right hemisphere of cerebellum;
	Top expressed in
	otic vesicle; ; superior frontal gyrus; ; neural layer of retina; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; spermatocyte; ; otolith organ; ; utricle; ; hand; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; cyclin-dependent protein kinase activity; protein binding; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity;
Cellular component	mediator complex; ciliary basal body; cytoplasm; cytoskeleton; cell projection; nucleus;
Biological process	traversing start control point of mitotic cell cycle; phosphorylation; positive regulation of MAPK cascade; negative regulation of cell population proliferation; protein phosphorylation; peptidyl-threonine phosphorylation; regulation of actin cytoskeleton organization; negative regulation of cilium assembly; cell projection organization;
	Sources:Amigo / QuickGO
Orthologs
	8558
	234854
	ENSG00000185324
	ENSMUSG00000033862
	Q15131
	Q3UMM4
	NM_001098533; NM_001160367; NM_003674; NM_052987; NM_052988
	NM_194444; NM_194446
	NP_001092003; NP_001153839; NP_443713; NP_443714
	NP_919426; NP_919428
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.^[7]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033862 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097–103. PMID 8208557.
^ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037–41. PMID 8084611.
^ ^a ^b "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10".
^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. S2CID 22792083.

External links

CDK10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033862 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8208557-5] Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097–103. PMID 8208557.

[pmid8084611-6] Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037–41. PMID 8084611.

[entrez-7] "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10".

[pmid11313931-8] Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. S2CID 22792083.

[1]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

Interactions

References

Further reading

External links