Fluoroethyl fluoroacetate

2-Fluoroethyl fluoroacetate
Names
	Preferred IUPAC name 2-Fluoroethyl fluoroacetate
	Other names TL-855
Identifiers
CAS Number	459-99-4;
3D model (JSmol)	Interactive image;
ChemSpider	9598;
PubChem CID	9992;
UNII	NR4H23SR3Q ;
CompTox Dashboard (EPA)	DTXSID20196651 ;
	InChI InChI=1S/C4H6F2O2/c5-1-2-8-4(7)3-6/h1-3H2 Key: ZIJVALRYXQXDOL-UHFFFAOYSA-N;
	SMILES C(CF)OC(=O)CF;
Properties
Chemical formula	FCH2CO2CH2CH2F
Molar mass	124.087 g·mol−1
Appearance	Liquid
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Extremely toxic
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	8500 ug/kg (mouse, subcutaneous)
LDLo (lowest published)	1 mg/kg (oral, rats)
LC50 (median concentration)	150 mg/m3, 10M (rat, inhalation); 450 ug/m3 (mouse, inhalation); 50 mg/m3 (rabbit, inhalation); 70 mg/m3, 10M (guinea pig, inhalation);
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Fluoroethyl fluoroacetate, or more accurately 2-fluoroethyl fluoroacetate, is an organic compound with the chemical formula F C H₂CO₂CH₂CH₂F. It is the fluoroacetate ester of 2-fluoroethanol, or in other words, the 2-fluoroethyl ester of fluoroacetic acid. 2-Fluoroethyl fluoroacetate is two times more toxic than methyl fluoroacetate.^[3]

References

^ ^a ^b "2-Fluoroethyl fluoroacetate".
^ Kitano, Hisao; Fukui, Ken-ichi; Nozu, Ryuzaburo; Osaka, Taichiro (1955). "(85) Some Reactions of Monofluoroacetic Acid Derivatives". The Journal of the Society of Chemical Industry, Japan (in Japanese). 58 (3): 224–226. doi:10.1246/nikkashi1898.58.224.
^ Saunders, B. C.; Stacey, G. J. (1949). "196. Toxic fluorine compounds containing the C–F link. Part IV. (a) 2-Fluoroethyl fluoroacetate and allied compounds. (b) 2 : 2′-Difluorodiethyl ethylene dithioglycol ether". J. Chem. Soc.: 916–919. doi:10.1039/JR9490000916.

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v t e Convulsants
GABA receptor antagonists	Bicuculline Bicyclic phosphates (TBPS, TBPO, IPTBO) BIDN Chlorophenylsilatrane Cicutoxin Cloflubicyne Coriamyrtin Dihydropicrotoxinin DMCM EBOB Endosulfan FG-7142 Fipronil Flurothyl Gabazine Oenanthotoxin Pentylenetetrazol Phenylsilatrane Picrotoxin p-CN-TBOB p-NCS-TBOB RDX TBOB Tetramethylenedisulfotetramine Thujone Trimethylolpropane phosphite Tutin
GABA synthesis inhibitors	3-Mercaptopropionic acid 4-Deoxypyridoxine Allylglycine Crimidine Decaborane Ginkgotoxin Isoniazid Pentaborane Thiocarbohydrazide Toxopyrimidine
Glycine receptor antagonists	Coriamyrtin Dendrobine Picrotoxin Strychnine Tutin
Glutamate receptor agonists	AMPA Domoic acid Kainic acid NMDA Quisqualic acid Tetrazolylglycine
Convulsant barbiturates	CHEB DMBB McN-481
Other	2,2,3,3-Tetrafluoropropyl trifluoromethyl ether Bromocamphor Camphor FAZ-4 Fluoroethyl fluoroacetate MC-2973 Methionine sulfoximine Methyl fluoroacetate Nitrocyclohexane Thebaine

v t e Derivatives of fluoroacetic acid and 2-fluoroethanol
Fluoroacetate salts	Aluminum fluoroacetate Ammonium fluoroacetate Barium fluoroacetate Cadmium fluoroacetate Calcium fluoroacetate Cupric fluoroacetate Potassium fluoroacetate Sodium fluoroacetate Thallous fluoroacetate Triethyllead fluoroacetate
Fluoroacetate esters	Allyl fluoroacetate Butyl fluoroacetate Cetyl fluoroacetate Cholesteryl fluoroacetate Ethyl fluoroacetate 2-Ethylhexyl fluoroacetate Fluoroacetylcholine Fluoroaspirin Fluoroethyl fluoroacetate Isopropyl fluoroacetate Methyl fluoroacetate Methylene bis(fluoroacetate) Phenyl fluoroacetate Propyl fluoroacetate
Fluoroethyl esters	Bis(2-fluoroethyl) carbonate Bis(2-fluoroethyl) hydrogen phosphite Bis(2-fluoroethyl) phosphorofluoridate Bis(2-fluoroethyl) sulfate Bis(2-fluoroethyl) sulfite Fluenetil Fluoroethyl acetate Fluoroethyl chloroacetate Fluoroethyl chloroformate Fluoroethyl chlorosulfonate Fluoroethyl fluoroacetate Fluoroethyl nitrite Fluoroethyl trichloroacetate Tetrakis(2-fluoroethyl) orthosilicate TL-790 TL-821 Tris(2-fluoroethyl) arsenite Tris(2-fluoroethyl) borate Tris(2-fluoroethyl) phosphite Tris(2-fluoroethyl) orthoformate
Fluoroacetamides	Fluoroacetamide Fluoroacetanilide Nissol
Other	Bis(2-fluoroethyl)ether 2-chloroethyl fluorothioacetate Fluoroacetic anhydride Fluoroacetyl chloride Fluoroacetyl fluoride