KLK12

KLK12
Identifiers
Aliases	KLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDs	OMIM: 605539; MGI: 1916761; HomoloGene: 44690; GeneCards: KLK12; OMA:KLK12 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,035,230 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,423,009 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; oral cavity; ; cervix epithelium; ; mucosa of pharynx; ; body of tongue; ; superior surface of tongue; ; vagina; ; minor salivary glands; ; amniotic fluid;
	Top expressed in
	esophagus; ; lip; ; embryo; ; stomach; ; skin of external ear; ; genital tubercle; ; skin of back; ; aorta; ; ascending aorta; ; nucleus of brain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; serine-type peptidase activity; peptidase activity; serine-type endopeptidase activity;
Cellular component	extracellular region; extracellular space; secretory granule;
Biological process	proteolysis; cornification;
	Sources:Amigo / QuickGO
Orthologs
	43849
	69511
	ENSG00000186474
	ENSMUSG00000044430
	Q9UKR0
	B2RVZ0
NM_019598; NM_145894; NM_145895; NM_001370125; NM_001370126;
	NM_001370127; NM_001370128
	NM_027097
NP_062544; NP_665901; NP_665902; NP_001357054; NP_001357055;
	NP_001357056; NP_001357057
	NP_081373
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.^[5]^[6]^[7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186474 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK12 kallikrein-related peptidase 12".

External links

The MEROPS online database for peptidases and their inhibitors: S01.020

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186474 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044430 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16800724-5] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-6] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-7] "Entrez Gene: KLK12 kallikrein-related peptidase 12".

[1]

References

Further reading

External links