Hexokinasis

Hexokinasis
Alia nomina	HK1, HK2, HK3, HK4
Numerus EC	2.7.1.1 transferasis

Substratum	hexosa

Hexokinasis (Numerus EC: 2.7.1.1) est quodvis enzymum, quod hexosum hexosa (sacchara cum sex atomis carbonii) in hexosi-6-phosphatum transferat^[1]. In itineris metabolico glycolysis hexokinasis enzymum primum est.

In hominibus isoformae I–IV (cum isoforma IV glucokinasis) notae sunt. Hexokinases in metabolitis fere omnium vitae formarum inveniuntur.

Inopia hexokinasis isoformae 1 (HK1) est morbus genetici ductus autosomaliter-recessivi speciem anaemiae haemolyticae chronicae causans.

Genetica

Geni isoformarum hexokinasum in diversis chromosomatibus inveniuntur. Nomen geni hexokinasis I, exempli gratia, est HK1, et locus cuius geneticus in chromosomate 10 humano est (10q22.1).

Metabolismus cancris et Warburg effectus

De Warburg effectus metabolismi maximi in cancri descriptus hac reactione hexokinasis molitus est. Variis cancrorum formis hexokinasis "ardens" est. Hac observatione nonnulla experimenta ad cancrum tractandum conata sunt (cancer pulmonis^[2]).

Nexus interni

Notae

↑ Uniprot de hexokinasi II humano
↑ Li W, Ma X, Li N, Liu H, Dong Q, Zhang J, Yang C, Liu Y, Liang Q, Zhang S, Xu C, Song W, Tan S, Rong P, Wang W (2016). "Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway". Exp Cell Res 349 (2): 320-7

[1] Uniprot de hexokinasi II humano

[2] Li W, Ma X, Li N, Liu H, Dong Q, Zhang J, Yang C, Liu Y, Liang Q, Zhang S, Xu C, Song W, Tan S, Rong P, Wang W (2016). "Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway". Exp Cell Res 349 (2): 320-7

[1]