Transportator serotonini

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Transportator serotonini (abbreviatura internationalis: SERT) est proteinum, quod serotoninum neurotransmissorem de fissura synaptica in bulbulus terminalis (praesynapsis) reportet. Nonnulla medicamenta ut inhibitores reabsortionis serotonini (IRS) vel inhibitores reabsorptionis serotonini noradrenalinique (IRSN) transportatorem serotonini obsidant. Non solum in depressione SERT momentum habere videtur, sed etiam syndromae Tourettensis^[1].

Natura genetica

Transportatoris serotoni SLC6A4 genum in chromosomate 17 humano in loco 17q11.2 situm est. Magnitudo geni 31 kilobasium (kb) cum 14 exonis extitit^[2]. Geni mutationes transportatoris inflexus quidem functionis efficiant^[3]. Proteino SERT 603 aminoacidorum cum duodecim regionibus transmembranaceis.

Notae

↑ Moya P. R., Wendland J. R., Rubenstein L. M., Timpano K. R., Heiman G. A., Tischfield J. A., King R. A., Andrews A. M., Ramamoorthy S., McMahon F. J., Murphy D. L. (2013). "Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder". Mov Disord 28 (9): 1263-70
↑ Lesch K. P., Balling U., Gross J., Strauss K., Wolozin B. L., Murphy D. L., Riederer P. (1994). "Organization of the human serotonin transporter gene". J Neural Transm Gen Sect 95 (2): 157-62
↑ Murphy D. L., Lesch K. P. (feb 2008). "Targeting the murine serotonin transporter: insights into human neurobiology". Nature Rev Neurosci 9: 85-96

Nexus interni

[1] Moya P. R., Wendland J. R., Rubenstein L. M., Timpano K. R., Heiman G. A., Tischfield J. A., King R. A., Andrews A. M., Ramamoorthy S., McMahon F. J., Murphy D. L. (2013). "Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder". Mov Disord 28 (9): 1263-70

[2] Lesch K. P., Balling U., Gross J., Strauss K., Wolozin B. L., Murphy D. L., Riederer P. (1994). "Organization of the human serotonin transporter gene". J Neural Transm Gen Sect 95 (2): 157-62

[3] Murphy D. L., Lesch K. P. (feb 2008). "Targeting the murine serotonin transporter: insights into human neurobiology". Nature Rev Neurosci 9: 85-96

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