Neurotenzinski receptor 2
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| Neurotenzinski receptor 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | NTSR2; NTR2 | ||||||||||
| Vanjski ID | OMIM: 605538 MGI: 108018 HomoloGene: 7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23620 | 18217 | |||||||||
| Ensembl | ENSG00000169006 | ENSMUSG00000020591 | |||||||||
| UniProt | O95665 | Q8VIF4 | |||||||||
| RefSeq (mRNA) | XM_001129997 | NM_008747 | |||||||||
| RefSeq (protein) | XP_001129997 | NP_032773 | |||||||||
| Lokacija (UCSC) | Chr 2: 11.72 - 11.73 Mb | Chr 12: 16.68 - 16.69 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neurotenzinski receptor tip 2 je protein koji je kod ljudi kodiran NTSR2 genom.[1][2][3]
Protein kodiran ovim genom pripada familiji G protein-spregnutih receptora koja aktivira sistem fosfatidilinozitol-kalcijum sekundarnih glasnika. Ispitivanja vezivanja i farmakologije su pokazala da ovaj receptor vezuje neurotenzin kao i nekoliko drugih liganda. Za razliku od NT1 receptora, ovaj gen prepoznaje sa visokim afinitetom levokabastin, antagonist histaminskog H1 receptora. Ova aktivnost sugeriše da ovaj receptor možda ima dodatni fiziološki značaj.[3]
- ↑ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (Jul 1996). „Molecular cloning of a levocabastine-sensitive neurotensin binding site”. FEBS Lett 386 (2-3): 91–4. DOI:10.1016/0014-5793(96)00397-3. PMID 8647296.
- ↑ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Feb 1999). „Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells”. Eur J Pharmacol 360 (2-3): 265–72. DOI:10.1016/S0014-2999(98)00678-5. PMID 9851594.
- ↑ 3,0 3,1 „Entrez Gene: NTSR2 neurotensin receptor 2”.
- Vincent JP, Mazella J, Kitabgi P (1999). „Neurotensin and neurotensin receptors.”. Trends Pharmacol. Sci. 20 (7): 302–9. DOI:10.1016/S0165-6147(99)01357-7. PMID 10390649.
- Mazella J, Botto JM, Guillemare E, et al. (1996). „Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.”. J. Neurosci. 16 (18): 5613–20. PMID 8795617.
- Ramez M, Bagot M, Nikolova M, et al. (2001). „Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes.”. J. Invest. Dermatol. 117 (3): 687–93. DOI:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
- Martin S, Vincent JP, Mazella J (2002). „Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.”. J. Cell. Sci. 115 (Pt 1): 165–73. PMID 11801734.
- Bourcier T, Rondeau N, Paquet S, et al. (2002). „Expression of neurotensin receptors in human corneal keratocytes.”. Invest. Ophthalmol. Vis. Sci. 43 (6): 1765–71. PMID 12036977.
- Leyton J, Garcia-Marin L, Jensen RT, Moody TW (2002). „Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.”. Eur. J. Pharmacol. 442 (3): 179–86. DOI:10.1016/S0014-2999(02)01539-X. PMID 12065070.
- Somaï S, Gompel A, Rostène W, Forgez P (2002). „Neurotensin counteracts apoptosis in breast cancer cells.”. Biochem. Biophys. Res. Commun. 295 (2): 482–8. DOI:10.1016/S0006-291X(02)00703-9. PMID 12150975.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Holst B, Holliday ND, Bach A, et al. (2005). „Common structural basis for constitutive activity of the ghrelin receptor family.”. J. Biol. Chem. 279 (51): 53806–17. DOI:10.1074/jbc.M407676200. PMID 15383539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- „Neurotensin Receptors: NTS2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.