WAY-317,538

WAY-317,538
(IUPAC) ime
	5-morfolin-4-il-pentanoinska kiselina (4-piridin-3-il-fenul)-amid
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
ChEMBL	CHEMBL1084615
Hemijski podaci
Formula	C20H25N3O2
Mol. masa	339,430
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24) ; Key: XCHIZTUBUXZESJ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Legal

WAY-317,538 (SEN-12333) je lek koji deluje kao potentan i selektivan pun agonist za α7 podtip neuronskih nikotinskih acetilholinskih receptora. On nije najpotentnije jedinjenje u seriji, ali je odabran za dalji razvoj zbog visoke selektivnosti u odnosu na srodne receptore, lakoće sinteze, i dobrih in vivo svojstava, uključujući visoku oralnu biodostupnost i dobru moždanu penetraciju.^[2] On ima nootropna i neuroprotektivna svojstva u životinjskim studijama, i izučava se kao potencijalni tretman za neurodegenerativna i neurokognitiva oboljenja uključujući Alchajmerovu bolest i šizofreniju.^[3]

Reference

↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Haydar, S.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.; Dunlop, J.; La Rosa, S.; Micco, I. i dr.. (2009). „SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist”. Bioorganic & Medicinal Chemistry 17 (14): 5247–5258. DOI:10.1016/j.bmc.2009.05.040. PMID 19515567.
↑ Roncarati, R.; Scali, C.; Comery, T.; Grauer, S.; Aschmi, S.; Bothmann, H.; Jow, B.; Kowal, D. i dr.. (2009). „Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders”. The Journal of Pharmacology and Experimental Therapeutics 329 (2): 459–468. DOI:10.1124/jpet.108.150094. PMID 19223665.

[Категорија:Никотински агонисти]]

[1] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[2] Haydar, S.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.; Dunlop, J.; La Rosa, S.; Micco, I. i dr.. (2009). „SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist”. Bioorganic & Medicinal Chemistry 17 (14): 5247–5258. DOI:10.1016/j.bmc.2009.05.040. PMID 19515567.

[3] Roncarati, R.; Scali, C.; Comery, T.; Grauer, S.; Aschmi, S.; Bothmann, H.; Jow, B.; Kowal, D. i dr.. (2009). „Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders”. The Journal of Pharmacology and Experimental Therapeutics 329 (2): 459–468. DOI:10.1124/jpet.108.150094. PMID 19223665.

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