Madhouse may refer to:
- Madhouse (1974), a 1974 horror film.
- There Was a Little Girl, also known as Madhouse, a 1981 horror film.
- Madhouse (1990), a 1990 comedy film.
- Madhouse (2004), a 2004 horror film.
- Madhouse (Trexmaster), a fanfic crossover.
- Madhouse, a Japanese animation studio.
For actual madhouses as portrayed in fiction, see Bedlam House.
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