ACSBG1

ACSBG1
Identifiers
Aliases	ACSBG1, BG, BG1, BGM, GR-LACS, LPD, acyl-CoA synthetase bubblegum family member 1
External IDs	OMIM: 614362; MGI: 2385656; HomoloGene: 9044; GeneCards: ACSBG1; OMA:ACSBG1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,245,688 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,569,154 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; inferior olivary nucleus; ; C1 segment; ; dorsal motor nucleus of vagus nerve; ; endothelial cell; ; internal globus pallidus; ; putamen; ; caudate nucleus; ; skin of arm; ; substantia nigra;
	Top expressed in
	lip; ; cerebellar cortex; ; deep cerebellar nuclei; ; adrenal gland; ; skin of external ear; ; visual cortex; ; esophagus; ; lobe of cerebellum; ; superior frontal gyrus; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; catalytic activity; ATP binding; decanoate-CoA ligase activity; long-chain fatty acid-CoA ligase activity; very long-chain fatty acid-CoA ligase activity;
Cellular component	cytosol; intracellular membrane-bounded organelle; endoplasmic reticulum; cytoplasmic vesicle; cytoplasm;
Biological process	lipid metabolism; very long-chain fatty acid metabolic process; response to glucocorticoid; fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; myelination; metabolism; long-chain fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23205
	94180
	ENSG00000103740
	ENSMUSG00000032281
	Q96GR2
	Q99PU5
	NM_001199377; NM_015162
	NM_053178
	NP_001186306; NP_055977
	NP_444408
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.^[5]^[6]^[7]

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.^[7] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103740 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032281 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.
^ ^a ^b "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".
^ Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.

External links

Human ACSBG1 genome location and ACSBG1 gene details page in the UCSC Genome Browser.

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Moriya-Sato A, Hida A, Inagawa-Ogashiwa M, et al. (2001). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem. Biophys. Res. Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pei Z, Oey NA, Zuidervaart MM, et al. (2004). "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation." J. Biol. Chem. 278 (47): 47070–8. doi:10.1074/jbc.M310075200. PMID 12975357.
Fraisl P, Forss-Petter S, Zigman M, Berger J (2004). "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase". Biochem. J. 377 (Pt 1): 85–93. doi:10.1042/BJ20031062. PMC 1223850. PMID 14516277.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Asheuer M, Bieche I, Laurendeau I, et al. (2005). "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy". Hum. Mol. Genet. 14 (10): 1293–303. doi:10.1093/hmg/ddi140. PMID 15800013.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103740 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032281 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid10954726-6] Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.

[entrez-7] "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".

[8] Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.

[1]

References

External links

Further reading