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Protein-coding gene in the species Homo sapiens
Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene .[ 5] [ 6]
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.[ 6]
EXOC5 has been shown to interact with Arf6 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000070367 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061244 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Guo W, Roth D, Gatti E, De Camilli P, Novick P (Apr 1997). "Identification and characterization of homologues of the Exocyst component Sec10p". FEBS Lett . 404 (2–3): 135–9. doi :10.1016/S0014-5793(97)00109-9 . PMID 9119050 . S2CID 43733804 . ^ a b "Entrez Gene: EXOC5 exocyst complex component 5" .^ Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P (Dec 2003). "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector" . J. Cell Biol . 163 (5): 1111–21. doi :10.1083/jcb.200305029 . PMC 2173613 PMID 14662749 .
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