Ponazuril

Ponazuril
Clinical data
Trade names	Marquis
Other names	ACD855; ACD-855
AHFS/Drugs.com	FDA Professional Drug Information
Routes of; administration	Oral
ATCvet code	QP51BC04 (WHO) ;
Legal status
Legal status	US: ℞-only; Veterinary use only;
Identifiers
	IUPAC name 1-Methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione;
CAS Number	69004-04-2 ;
PubChem CID	3050408;
ChemSpider	2312474 ;
UNII	JPW84AS66U;
CompTox Dashboard (EPA)	DTXSID7048958 ;
ECHA InfoCard	100.157.907
Chemical and physical data
Formula	C18H14F3N3O6S
Molar mass	457.38 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F;
	InChI InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) ; Key:VBUNOIXRZNJNAD-UHFFFAOYSA-N ;
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Ponazuril (INN), sold by Merial, Inc.,^[1] now part of Boehringer Ingelheim,^[2] under the trade name Marquis® (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.^[3]^[4] Veterinarians have been preparing a formulary version of the medication for use in small animals such as cats, dogs, and rabbits against coccidia as an intestinal parasite. Coccidia treatment in small animals is far shorter than treatment for EPM.^{[citation needed]} Along with its analogue ACD856, ponazuril (also known as ACD855) is a positive allosteric modulator of the tropomyosin receptor kinases TrkA and TrkB.^[5]

References

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