WAY-100,135

WAY-100,135
(IUPAC) ime
	(S)-N-tert-butil- 3-(4-(2-metoksifenil)- piperazin-1-il)- 2-fenilpropanamid
Klinički podaci
Identifikatori
CAS broj	133025-23-7
ATC kod	?
PubChem	115111
Hemijski podaci
Formula	C24H33N3O2
Mol. masa	395.536 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H33N3O2/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4/h5-13,20H,14-18H2,1-4H3,(H,25,28) ; Key: UMTDAKAAYOXIKU-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

WAY-100,135 je piperazinski lek i istraživačka hemikalija koja se koristi u naučnim istraživanjima. Za njega se originalno smatralo da deluje kao selektivni antagonist 5-HT_1A receptora, ali su naknadna istraživanja pokazala da on takođe deluje kao parcijalni agonist 5-HT_1B i 5-HT_1D receptora.^[3]^[4]

Povezano

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Cliffe IA, Brightwell CI, Fletcher A, Forster EA, Mansell HL, Reilly Y, Routledge C, White AC. (1993). „(S)-N-tert-butyl- 3-(4-(2-methoxyphenyl)- piperazin-1-yl)- 2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.”. J Med Chem. 36 (10): 1509–1510. DOI:10.1021/jm00062a028. PMID 8496920.
↑ Davidson C, Ho M, Price GW, Jones BJ, Stamford JA. (1997). „(+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors.”. Br J Pharmacol. 121 (4): 737–742. DOI:10.1038/sj.bjp.0701197. PMC 1564750. PMID 9208142.

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